Why does prostate cancer happen?

Ultimately, mutations in your DNA, or genetic material, lead to the growth of cancerous cells. These mutations cause cells in your prostate to start growing uncontrollably and abnormally. Abnormal or cancerous cells continue to grow and divide until a tumor develops.

healthline.com - Prostate Cancer: Causes and Risk Factors - Healthline

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According to the Urology Care Foundation , prostate cancer is the second most common cause of all cancer-related deaths among American men. About 1 in 7 men will be diagnosed with the disease in their lifetime. Approximately 1 in 39 men will die from it. Most of these deaths occur among older men. The prostate is a small gland located underneath the bladder in men and is part of the reproductive system. Some men develop prostate cancer, usually later in life. If cancer develops on your prostate gland, it will likely grow slowly. In rare cases, the cancer cells may be more aggressive, grow quickly, and spread to other areas of your body. The earlier your doctor finds and treats the tumor, the higher the chances are of finding curative treatment. Ultimately, mutations in your DNA, or genetic material, lead to the growth of cancerous cells. These mutations cause cells in your prostate to start growing uncontrollably and abnormally. Abnormal or cancerous cells continue to grow and divide until a tumor develops. If you have an aggressive type of prostate cancer, the cells may metastasize, or leave the original tumor site and spread to other parts of your body. Like all types of cancer, the exact cause of prostate cancer isn’t easy to determine. In many cases, multiple factors may be involved, including genetics and exposure to environmental toxins, like certain chemicals or radiation. Some risk factors may affect your chances of developing prostate cancer, including your:

family history

age

race

geographical location

diet

Family history

In some cases, the mutations that lead to prostate cancer are inherited. If you have a family history of prostate cancer, you’re at increased risk of developing the disease yourself, because you may have inherited damaged DNA. According to the American Cancer Society , approximately 5-10 percent of prostate cancer cases are caused by inherited mutations. It’s been linked to inherited mutations in several different genes, including:

RNASEL, formerly known as HPCI

BRCA1 and BRCA2, which have also been linked to breast and ovarian cancer in women

MSH2, MLH1, and other DNA mismatch repair genes

HOXB13

Age

One of the biggest risk factors for prostate cancer is age. This disease rarely affects young men. The Prostate Cancer Foundation reports that only 1 in 10,000 men under the age of 40 in the United States will develop it. That number jumps to 1 in 38 for men between the ages of 40 and 59. It leaps to 1 in 14 men between the ages of 60 and 69. The majority of cases are diagnosed in men over 65. Age Incidence of prostate cancer <40 1 in 10,000 men 40-59 1 in 38 men 60-69 1 in 14 men

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Race and ethnicity

Although the reasons aren’t fully understood, race and ethnicity are risk factors for prostate cancer. According to the American Cancer Society , in the United States, Asian-American and Latino men have the lowest incidences of prostate cancer. In contrast, African-American men are more likely to develop the disease than men of other races and ethnicities. They’re also more likely to be diagnosed at a later stage and have a poor outcome. They’re twice as likely to die from prostate cancer as white men.

Diet

A diet that’s rich in red meat and high-fat dairy products may also be a risk factor for prostate cancer, though there’s limited research. One study published in 2010 looked at 101 cases of prostate cancer and found a correlation between a diet high in meat and high-fat dairy products and prostate cancer, but stressed the need for additional studies. A more recent study from 2017 looked at the diet of 525 men newly diagnosed with prostate cancer and found an association between high-fat milk consumption and the progression of the cancer. This study suggests that high-fat milk consumption may also play a role in the development of prostate cancer. Men who eat diets high in meat and high-fat dairy products also seem to eat fewer fruits and vegetables. Experts don’t know if the high levels of animal fat or the low levels of fruits and vegetables contribute more to dietary risk factors. More research is needed.

Geographical location

Where you live can also impact your risk of developing prostate cancer. While Asian men living in America have a lower incidence of the disease than those of other races, Asian men living in Asia are even less likely to develop it. According to the American Cancer Society , prostate cancer is more common in North America, the Caribbean, northwestern Europe, and Australia than it is in Asia, Africa, Central America, and South America. Environmental and cultural factors may play a role.

healthline.com - Prostate Cancer: Causes and Risk Factors - Healthline

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