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Why are tomatoes good for prostate?

Earlier research in the Adventist Health Study and several other projects internationally suggest high lycopene intake is associated with reduced risk of prostate cancer. Tomato and tomato-based products are of particular interest as they are major sources of the carotenoid lycopene.

wcrf.org - Cooked tomatoes can reduce the risk of prostate cancer

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Dr Gary Fraser is a Professor of Medicine and Epidemiology at Loma Linda University Health, and the former primary director of the Adventist Health Study; a prospective cohort study of 96,000 Seventh-day Adventist men and women in the US and Canada. His latest research, funded by World Cancer Research Fund (WCRF), is revealing a fascinating link between tomatoes and prostate cancer. Prostate cancer is the second most common cancer worldwide. In the US, there were an estimated 165,000 new cases of prostate cancer and nearly 30,000 deaths in 2018. Since 1989, a research team at Loma Linda University Health has examined a number of dietary practices to see which offer promise in preventing chronic diseases such as heart disease and cancer. Earlier research in the Adventist Health Study and several other projects internationally suggest high lycopene intake is associated with reduced risk of prostate cancer. Tomato and tomato-based products are of particular interest as they are major sources of the carotenoid lycopene. Seventh-day Adventists are well-known for encouraging their members to adopt healthy lifestyle practices. Loma Linda University Health is conducting what is widely recognised as the largest ongoing research of Adventists’ dietary choices and healthy living habits. To examine how tomato consumption may impact the development of prostate cancer, we looked for significant relationships between diet and prostate cancer in nearly 28,000 Adventist men in the US.

How our research was done

All Adventist Health Study participants agree to fill out self-administered food frequency questionnaires reporting the average number of times per week they ate approximately 200 different foods and beverages, and the serving sizes. After tracking the study’s male participants, all of whom were cancer-free when they enrolled in the project, we found that 1,226 of them had been diagnosed with prostate cancer, and 355 of those were aggressive cases. As we focused on dietary lycopene levels, we found that men who consumed canned and cooked tomatoes five to six times a week had a 28 per cent decreased risk of prostate cancer compared with men who never consumed this food. The effect was still significant even after adjusting for potential confounders including ethnicity, education, obesity, exercise levels, alcohol consumption and others. Interestingly, we found no significant association between prostate cancer and consumption of raw tomatoes, tomato soup, tomato sauce and tomato-based vegetable juice. While all tomatoes and tomato-based products contain lycopene, other studies have shown that lycopene is absorbed at different rates depending on the product consumed. Lycopene bioavailability is higher when tomatoes have been heated or cooked, and especially if cooked with oil. Processing tomatoes in this way contributes to the separation of the lycopene from the carrier proteins.

Our conclusion for cancer prevention

This research suggests that it is particularly cooked tomatoes that may play a significant role in reducing a man’s risk of developing prostate cancer. It may be their lycopene content that is the active principle. We will continue to look at tomato products and their potential to reduce prostate cancer risk. Still, men concerned about developing prostate cancer could consider adding cooked and canned tomatoes to their diet on a regular basis.

> More information on Dr Fraser’s WCRF-funded work can be found here

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Does red wine help the prostate?

But the scientists went one step further by evaluating each type of alcoholic beverage independently. Here the news was surprising—wine drinking was linked to a reduced risk of prostate cancer. And when white wine was compared with red, red had the most benefit.

health.harvard.edu - Prostate benefits from red wine - Harvard Health

June 1, 2007

Researchers have found that men who drink an average of four to seven glasses of red wine per week are only 52% as likely to be diagnosed with prostate cancer as those who do not drink red wine, reports the June 2007 issue of Harvard Men’s Health Watch. In addition, red wine appears particularly protective against advanced or aggressive cancers. Researchers in Seattle collected information about many factors that might influence the risk of prostate cancer in men between ages 40 and 64, including alcohol consumption. At first the results for alcohol consumption seemed similar to the findings of many earlier studies: There was no relationship between overall consumption and risk. But the scientists went one step further by evaluating each type of alcoholic beverage independently. Here the news was surprising—wine drinking was linked to a reduced risk of prostate cancer. And when white wine was compared with red, red had the most benefit. Even low amounts seemed to help, and for every additional glass of red wine per week, the relative risk declined by 6%.

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