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Who should not take spinach?

But spinach is LIKELY UNSAFE for infants that are less than 4 months old. The nitrates in spinach can sometimes cause a blood disorder (methemoglobinemia) in young infants. Allergies: People who are sensitive to latex or certain molds are more likely to have allergic responses to spinach.

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Bajpai, M., Mishra, A., and Prakash, D. Antioxidant and free radical scavenging activities of some leafy vegetables. Int J Food Sci Nutr 2005;56(7):473-481. View abstract. Brogren, M. and Savage, G. P. Bioavailability of soluble oxalate from spinach eaten with and without milk products. Asia Pac.J.Clin.Nutr. 2003;12(2):219-224. View abstract. Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., and White, W. S. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am.J.Clin.Nutr. 2004;80(2):396-403. View abstract. Castenmiller, J. J., West, C. E., Linssen, J. P., het Hof, K. H., and Voragen, A. G. The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans. J.Nutr. 1999;129(2):349-355. View abstract. Charatan, F. FDA warns US consumers not to eat spinach after E coli outbreak. BMJ 9-30-2006;333(7570):673. View abstract. E. coli O157:H7 outbreak in the United States associated with bagged fresh spinach. Can.Commun.Dis.Rep. 11-15-2006;32(22):272. View abstract. Faivre, J., Faivre, M., Klepping, C., and Roche, L. [Methemoglobinemias caused by ingestion of nitrites and nitrates]. Ann.Nutr.Aliment. 1976;30(5-6):831-838. View abstract. Faulks, R. M., Hart, D. J., Brett, G. M., Dainty, J. R., and Southon, S. Kinetics of gastro-intestinal transit and carotenoid absorption and disposal in ileostomy volunteers fed spinach meals. Eur.J.Nutr. 2004;43(1):15-22. View abstract. Gustafsson, K., Asp, N. G., Hagander, B., and Nyman, M. Satiety effects of spinach in mixed meals: comparison with other vegetables. Int.J.Food Sci.Nutr. 1995;46(4):327-334. View abstract. Heaney, R. P., Weaver, C. M., and Recker, R. R. Calcium absorbability from spinach. Am.J.Clin.Nutr. 1988;47(4):707-709. View abstract. Jian, L., Du, C. J., Lee, A. H., and Binns, C. W. Do dietary lycopene and other carotenoids protect against prostate cancer? Int.J.Cancer 3-1-2005;113(6):1010-1014. View abstract.

Kubler, W. [Methemoglobinemia caused by spinach in infancy]. Dtsch.Med.Wochenschr. 10-15-1965;90(42):1881-1882. View abstract.

Lomnitski, L., Bergman, M., Nyska, A., Ben Shaul, V., and Grossman, S. Composition, efficacy, and safety of spinach extracts. Nutr.Cancer 2003;46(2):222-231. View abstract. Morrow, S. A., Nabity, S. A., Ehlers, S. J., Cottrell, S. A., Rhee, J. T., Loyal, J. K., and Schulz, E. N. Corrections to the report of San Mateo County enterohemorrhagic Escherichia coli O157:h7 outbreak associated with raw spinach. J.Am.Geriatr.Soc. 2007;55(1):140-141. View abstract. Ongoing multistate outbreak of Escherichia coli serotype O157:H7 infections associated with consumption of fresh spinach--United States, September 2006. MMWR Morb.Mortal.Wkly.Rep. 9-29-2006;55(38):1045-1046. View abstract. Porrini, M., Riso, P., and Oriani, G. Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations. Eur.J.Nutr. 2002;41(3):95-100. View abstract. Rai, A., Mohapatra, S. C., and Shukla, H. S. Correlates between vegetable consumption and gallbladder cancer. Eur J Cancer Prev. 2006;15(2):134-137. View abstract. Roller, E., Meller, S., Homey, B., Ruzicka, T., and Neumann, N. J. [Contact dermatitis caused by spinach, hedge mustard and chives]. Hautarzt 2003;54(4):374-375. View abstract.

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Sanchez, I., Rodriguez, F., Garcia-Abujeta, J. L., Fernandez, L., Quinones, D., and Martin-Gil, D. Oral allergy syndrome induced by spinach. Allergy 1997;52(12):1245-1246. View abstract. Sander, C. and Jacobi, H. [Methemoglobin poisoning in a 2-year old boy after eating spinach]. Z.Kinderheilkd. 1967;98(3):222-226. View abstract. Schreiber, J., Muller, E., Becker, W. M., Zabel, P., Schlaak, M., and Amthor, M. [Spinach powder-induced exogenous allergic alveolitis]. Pneumologie 1998;52(1):61-65. View abstract. Schuller, A., Morisset, M., Maadi, F., Kolopp Sarda, M. N., Fremont, S., Parisot, L., Kanny, G., and Moneret-Vautrin, D. A. Occupational asthma due to allergy to spinach powder in a pasta factory. Allergy 2005;60(3):408-409. View abstract.

Scrimshaw, N. S. Iron deficiency. Sci.Am. 1991;265(4):46-52. View abstract.

Simon, C. [Poisoning by nitrites after ingestion of spinach (a form of methemoglobinemia)]. Arch.Fr.Pediatr. 1966;23(2):231-238. View abstract. Smeenk, C. and van Oudheusden, A. P. [Hemoglobinemia caused by spinach water]. Ned.Tijdschr.Geneeskd. 7-27-1968;112(30):1378-1379. View abstract. Tokui, N., Yoshimura, T., Fujino, Y., Mizoue, T., Hoshiyama, Y., Yatsuya, H., Sakata, K., Kondo, T., Kikuchi, S., Toyoshima, H., Hayakawa, N., Kubo, T., and Tamakoshi, A. Dietary habits and stomach cancer risk in the JACC Study. J.Epidemiol. 2005;15 Suppl 2:S98-108. View abstract. Ahn YO. Diet and stomach cancer in Korea. Int J Cancer 1997;Suppl 10:7-9. View abstract. Bolton-Smith C, Price RJ, Fenton ST, et al. Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr 2000;83:389-99. View abstract. Bondonno CP, Downey LA, Croft KD, et al. The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women. Food Funct. 2014;5(5):849-58. View abstract. Drouet, M., Le Sellin, J., Gay, G., el Founini, M., and Sabbah, A. [Allergy to Chenopodiaceae (beets, spinach) associated with latex allergy]. Allerg.Immunol.(Paris) 1994;26(3):113-114. View abstract. Ferrer M, Redón B, Bartolomé B, Michavila A. Food allergy to spinach in an infant. Allergol Immunopathol (Madr). 2011;39(6):378-9. View abstract. Herrera-Mozo, I., Ferrer, B., Luis Rodriguez-Sanchez, J., and Juarez, C. Description of a novel panallergen of cross-reactivity between moulds and foods. Immunol.Invest 2006;35(2):181-197. View abstract. Joseph JA, Shukitt-Hale B, Denisova NA, et al. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 1998;18:8047-55. View abstract. Joseph JA, Shukitt-Hale B, Denisova NA, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999;19:8114-21. View abstract. Karlson, B., Leijd, B., and Hellstrom, K. On the influence of vitamin K-rich vegetables and wine on the effectiveness of warfarin treatment. Acta Med Scand. 1986;220(4):347-350. View abstract. Maillard, H., Lemerle, E., Garot, D., Leclech, C., and Machet, L. [Crossed spinach-latex allergy revealed by exercise-induced anaphylaxis]. Allerg.Immunol.(Paris) 1999;31(5):156-157. View abstract.

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Maillard, H., Machet, L., Meurisse, Y., Garot, D., Toledano, C., Jan, V., and Vaillant, L. Cross-allergy to latex and spinach. Acta Derm.Venereol. 2000;80(1):51. View abstract. Mokhtari E, Farhadnejad H, Salehi-Sahlabadi A, et al. Spinach consumption and nonalcoholic fatty liver disease among adults: a case-control study. BMC Gastroenterol 2021;21(1):196. View abstract. Montelius C, Erlandsson D, Vitija E, Stenblom EL, Egecioglu E, Erlanson-Albertsson C. Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women. Appetite. 2014;81:295-304. View abstract. Montelius C, Erlandsson D, Vitija E, Stenblom EL, Egecioglu E, Erlanson-Albertsson C. Corrigendum to "Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women" [Appetite 81 (2014), 295-304]. Appetite. 2016;101:239. View abstract. Rebello CJ, Chu J, Beyl R, Edwall D, Erlanson-Albertsson C, Greenway FL. Acute effects of a spinach extract rich in thylakoids on satiety: A randomized controlled crossover trial. J Am Coll Nutr. 2015;34(6):470-7. View abstract. Roberts JL, Moreau R. Functional properties of spinach (Spinacia oleracea L.) phytochemicals and bioactives. Food Funct. 2016;7(8):3337-53. View abstract. Seddon JM, Ajani UA, Sperduto R, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 1994;272:1413-20. View abstract. Sharapov UM, Wendel AM, Davis JP, OUTBREAK INVESTIGATION TEAM. Multistate outbreak of Escherichia coli O157:H7 infections associated with consumption of fresh spinach: United States, 2006. J Food Prot. 2016;79(12):2024-2030. View abstract. Stenblom EL, Egecioglu E, Landin-Olsson M, Erlanson-Albertsson C. Consumption of thylakoid-rich spinach extract reduces hunger, increases satiety and reduces cravings for palatable food in overweight women. Appetite. 2015;91:209-19. View abstract. Stenblom EL, Montelius C, Östbring K, et al. Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women. Appetite. 2013;68:118-23. View abstract. Tabrizi FPF, Farhangi MA, Vaezi M, Hemmati S. The effects of spinach-derived thylakoid supplementation in combination with calorie restriction on anthropometric parameters and metabolic profiles in obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial. Nutr J 2020;19(1):82. View abstract. Waseem M, Akhtar S, Manzoor MF, et al. Nutritional characterization and food value addition properties of dehydrated spinach powder. Food Sci Nutr 2021;9(2):1213-1221. View abstract.

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