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While a couple of glasses of red wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well.
Memory and other thinking problems have many possible causes, including depression, an infection, or medication side effects. Sometimes, the...
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US Results Quality of Care No City 1 Boston 75.36 2 Los Angeles 80.29 3 New York 69.78 23 more rows
Read More »While a couple of glasses of red wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study, which appears in the journal Scientific Reports, shows that low levels of alcohol consumption tamp down inflammation and helps the brain clear away toxins, including those associated with Alzheimer’s disease. “Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system,” said Maiken Nedergaard, M.D., D.M.Sc., co-director of the Center for Translational Neuromedicine at the University of Rochester Medical Center (URMC) and lead author of the study. “However, in this study we have shown for the first time that low doses of alcohol are potentially beneficial to brain health, namely it improves the brain’s ability to remove waste.” The finding adds to a growing body of research that point to the health benefits of low doses of alcohol. While excessive consumption of alcohol is a well-documented health hazard, many studies have linked lower levels of drinking with a reduced risk of cardiovascular diseases as well as a number of cancers. Nedergaard’s research focuses on the glymphatic system, the brain’s unique cleaning process that was first described by Nedergaard and her colleagues in 2012. They showed how cerebral spinal fluid (CSF) is pumped into brain tissue and flushes away waste, including the proteins beta amyloid and tau that are associated with Alzheimer’s disease and other forms of dementia. Subsequent research has shown that the glymphatic system is more active while we sleep, can be damaged by stroke and trauma, and improves with exercise. The new study, which was conducted in mice, looked at the impact of both acute and chronic alcohol exposure. When they studied the brains of animals exposed to high levels of alcohol over a long period of time, the researchers observed high levels of a molecular marker for inflammation, particularly in cells called astrocytes which are key regulators of the glymphatic system. They also noted impairment of the animal’s cognitive abilities and motor skills. Animals that were exposed to low levels of alcohol consumption, analogous to approximately 2 ½ drinks per day, actually showed less inflammation in the brain and their glymphatic system was more efficient in moving CSF through the brain and removing waste, compared to control mice who were not exposed to alcohol. The low dose animals’ performance in the cognitive and motor tests was identical to the controls. “The data on the effects of alcohol on the glymphatic system seemingly matches the J-shaped model relating to the dose effects of alcohol on general health and mortality, whereby low doses of alcohol are beneficial, while excessive consumption is detrimental to overall health” said Nedergaard. “Studies have shown that low-to-moderate alcohol intake is associated with a lesser risk of dementia, while heavy drinking for many years confers an increased risk of cognitive decline. This study may help explain why this occurs. Specifically, low doses of alcohol appear to benefit overall brain health.” Additional co-authors include Iben Lundgaard, Wei Wang, Allison Eberhardt, Hanna Vinitsky, Benjamin Reeves, Sisi Peng, Nanhong Lou, and Rashid Hussein with URMC. Nedergaard maintains research labs at both URMC and the University of Copenhagen in Denmark. The study was funding with support from the Department of Navy’s Office of Naval Research, the National Institute of Neurological Disorders and Stroke, and the National Institute on Aging.
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Read More »For most people, there are no serious dangers involved in eating one meal a day, other than the discomforts of feeling hungry. That said, there are some risks for people with cardiovascular disease or diabetes. Eating one meal a day can increase your blood pressure and cholesterol.
The “One Meal a Day” diet, or OMAD diet, claims to help you lose weight by forcing your body to burn fat. It’s a type of intermittent fasting, which alternates between periods throughout the day in which you can eat anything and periods in which you don’t eat at all. OMAD is particularly strict because you don’t eat for 23 hours, then consume all of your calories in a single meal. How It Works Like other kinds of intermittent fasting, eating one meal a day is a way of manipulating how your body finds and uses fuel. When you eat in a more traditional pattern, your energy comes from the food that you eat. When you take in carbohydrates, your body breaks them down into sugars. If you have more sugar in your blood than you need, a chemical called insulin will carry the extra into your fat cells. When you don’t eat for extended periods of time, your body produces less insulin. Your cells still need energy for fuel, so your fat cells release energy to compensate. For this to happen, however, you have to avoid eating for long enough that your insulin levels drop.
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