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Where is the first place cancer spreads?

The lungs are the most common organ for cancers to spread to. This is because the blood from most parts of the body flows back to the heart and then to the lungs. Cancer cells that have entered the bloodstream can get stuck in the small blood vessels (capillaries) of the lungs.

cancerresearchuk.org - Where cancer can spread
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This page tells you about where cancers can spread. Cancer can spread to:

Where can cancer spread to

Cells can break away from a cancer and spread in the blood or lymphatic systems to almost anywhere in the body. But most types of cancer tend to spread to one or 2 places in the body

You can read about how cancer can spread.

The lungs

The lungs are the most common organ for cancers to spread to. This is because the blood from most parts of the body flows back to the heart and then to the lungs. Cancer cells that have entered the bloodstream can get stuck in the small blood vessels (capillaries) of the lungs. You may not have any symptoms if cancer spreads to the lungs. Or it might cause:

a cough that doesn't go away

shortness of breath

chest infections

a build up of fluid between the chest wall and the lung called a pleural effusion – this can cause shortness of breath, chest pain and discomfort Fluid builds up because cancer cells can cause inflammation in the 2 sheets of tissue that cover the lungs (the pleural membrane). The inflamed tissues make extra fluid and the fluid collects between the membranes. There may also be cancer cells in the pleural space that stop the extra fluid draining away. The lungs expand (inflate) as we breathe in. This fluid build up gets in their way and presses on the lungs, stopping them from expanding fully. The treatment for cancer that has spread to the lung (secondary lung cancer) depends on where the cancer started in the body (the primary cancer). So breast cancer that has spread to the lungs is usually treated like a breast cancer, not like lung cancer.

You can read about treatment to drain fluid on the lung.

The liver

Many types of cancer can spread to the liver. However, it is most likely to happen in cancers of the digestive system. This is because the blood from the digestive system circulates through the liver before it goes back to the heart. The cancer cells may get stuck in the small capillaries of the liver. Cancer that has spread to the liver may not cause any symptoms. But it may cause:

lack of energy

feeling generally unwell

feeling sick

lack of appetite

pain on the right side of the body under the rib cage

yellowing of the skin and whites of the eyes (jaundice)

a build up of fluid in the abdomen (ascites)

Jaundice is caused from a blockage in the bile ducts or your liver not working properly. This causes:

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the skin and whites of the eyes to turn yellow

itchy skin

the urine to look dark and poo can look pale

Ascites is the name for a build up of fluid in the tummy (abdomen). The abdomen contains many organs such as the stomach, bowels and liver. These organs are covered by a sheet of tissue (membrane) called peritoneum. The peritoneum is made up of 2 layers. One that lines the wall of the abdomen and the other covers the organs. Sometimes fluid can build up between the 2 layers, which can be very uncomfortable. Fluid can build up because: cancer cells can irritate the lining of the abdomen and make it produce too much fluid

lymph glands in the abdomen get blocked and can't drain fluid properly

cancer spread in the liver raises the pressure in nearby blood vessels, which forces fluid out the liver can't make enough blood proteins so fluid leaks out of the veins into the abdominal cavity

​​

You can read about fluid in the abdomen and its treatment.

The lymph nodes

It's very common for cancer cells to travel from where they started in the body, to nearby lymph nodes. This is because there is a natural circulation of tissue fluid from the organs into the lymphatic system. This is not the same as having a cancer of the lymphatic system, such as lymphoma. When cancer spreads to the lymph nodes it may make them swell up. The swollen lymph nodes are easy to see if they are near the surface of the body – for example, in the neck or under the arm. But if the nodes are deeper in the body doctors can only see them on a scan. Cancer in the lymph nodes may not cause any symptoms. But sometimes, the swollen lymph nodes can block the circulation of tissue fluid. This can cause swelling in the affected part of the body. For example, swollen lymph nodes in the armpit or groin can cause swelling in the arm or leg on the same side of the body. This swelling is called lymphoedema.

You can read detailed information about lymphoedema.

The bones

Some cancers are likely to spread to the bones. For example prostate cancer, breast cancer and lung cancer.

The most common effects of secondary cancer in the bones are:

pain in the affected bones

weakness in the affected bones

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You get pain because the cancer cells multiply in the bone and press on nerves. The growing cancer can weaken the bone by damaging its normal structure. This can make the bone more likely to break (a pathological fracture).

You can find out about secondary bone cancers and their treatment.

Damaged bone cells can release calcium into the blood. High levels of calcium in the blood may cause:

feeling sick

feeling tired, drowsy or muddled

constipation

feeling very thirsty

Very high calcium levels can cause irritability, confusion and eventually unconsciousness.

We have information about cancer and high blood calcium levels.

The brain

Some types of cancer can spread to the brain, such as lung cancer and breast cancer. Sometimes colon (bowel) cancer, kidney cancer, melanoma and other cancers can also spread to the brain.

The most common symptoms of cancer spread to the brain are:

headaches

feeling sick

These symptoms happen because there is a limited amount of space for the brain within the skull. So the growing cancer causes an increase in pressure inside the skull. This is called raised intracranial pressure. Other symptoms depend on which part of the brain the cancer is growing in. They also depend on the size of the tumour (or tumours). Small secondary brain tumours may not cause many symptoms. Or it may cause:

weakness in an arm, leg, or on one side of the body

moodiness or changes in behaviour

fits (seizures)

confusion

drowsiness

a feeling of the room spinning (vertigo)

feeling dizzy or unsteady

You can read about secondary brain tumours and their treatment.

The skin

Sometimes cancer cells can start growing in the skin. The secondary skin cancer may start to grow on or near the scar after an operation to remove the primary cancer. Or sometimes secondary skin cancers can grow in other parts of the body. A secondary skin cancer may look like a pink or red raised lump (a bit like a boil). Doctors may call these areas plaques or nodules. It is important to tell your doctor if you think you have one as they can give you treatment. Without treatment, the area may become bigger and may bleed or ooze fluid. This is called an ulcerating cancer. You may find it helpful to read our information about why some cancers come back after treatment.

cancerresearchuk.org - Where cancer can spread
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