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What should PSA be 5 years after radiation?

Researchers concluded that when PSA levels remain low (less than 2 ng/mL) five years after external beam radiation therapy, the great majority of patients will be biochemically disease-free at 10 years.

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The level of prostate-specific antigen (PSA) in the blood of prostate cancer patients five years after radiation treatment can help predict their disease-free survival for the next several years, according to the October 2002 issue of the International Journal of Radiation Oncology, Biology and Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology. Researchers have discovered that patients who maintain very low five-year PSA levels have a very low probability of relapse at 10 years and beyond. The study identified 328 men treated with external beam radiation therapy to the prostate who were biochemically disease-free five years after treatment. The median follow-up was 7.4 years. The patients were divided into four groups according to their PSA values five years after treatment: PSA less than or equal to 0.5, 0.5 to 1.0, 1.0 to 2.0 and 2.0 to 4.0 ng/mL. PSA progression-free rates were calculated in each subgroup at 10 years after treatment. The PSA progression-free survival rate was 87 percent, 79 percent and 67 percent, respectively, 8, 10 and 13 years after treatment in patients biochemically free of disease five years after treatment. The progression-free rates at 10 years after treatment according to the PSA level at five years was 92 percent for PSA less than or equal to 0.5 ng/mL, 71 percent for PSA 0.5 to 1.0 ng/mL, 78 percent for PSA 1.0 to 2.0 ng/mL and 56 percent for PSA 2.0 to 4.0 ng/mL. The lower the PSA level at five years, the more durable the probability of maintained biochemical disease-free survival. Researchers concluded that when PSA levels remain low (less than 2 ng/mL) five years after external beam radiation therapy, the great majority of patients will be biochemically disease-free at 10 years. The hazard rates of biochemical progression in the 6 to 10 years after treatment are low and are comparable to rates seen when prostatectomy (surgical removal of the prostate) is the chosen treatment modality. "This study reinforces the fact that radiation therapy should be used to achieve low PSA levels early in treatment, and those low levels should be maintained to five years and beyond," said Anthony L. Zietman, M.D., of the Department of Radiation Oncology at Massachusetts General Hospital and co-author of the study. "If this can be achieved, the long-term outlook for prostate cancer patients treated with radiation therapy will be good."

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Imagine Your Moment Of Freedom!
Imagine Your Moment Of Freedom!

Fluxactive Complete is conveniently packed with over 14 essential prostate powerhouse herbs, vitamins and grade A nutrients which work synergistically to help you support a healthy prostate faster

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Does red wine increase testosterone in men?

A compound in red wine could increase levels of testosterone circulating in your body by inhibiting the way you excrete the hormone, according to new research in Nutrition Journal.

A compound in red wine could increase levels of testosterone circulating in your body by inhibiting the way you excrete the hormone, according to new research in Nutrition Journal. Normally, one of the ways testosterone is eliminated from your body is through urine. An enzyme called UGT2B17 attaches specific molecules to testosterone, enabling your body to get rid of it. But researchers at Kingston University in London found that quercetin--a compound in red wine--blocks UGT2B17 in lab studies. That means potentially elevated T levels in your bloodstream, and less in your urine. What does that mean for you? Researchers aren't sure yet. "This is a classic example of a study done in a test tube that potentially might have implications for humans, but there are many steps that need to be taken to see if these findings can be translated to humans," says Dr. Michael Joyner, an exercise researcher at the Mayo Clinic. In the meantime, enjoy your wine--but stick to a glass or two max a night. Chugging wine--or any alcohol for that matter--could tank your T levels, not boost them. Men who boozed even moderately every day for 3 weeks had a 7 percent decrease in testosterone levels, according to a recent Dutch study. For more ways to boost your T, eat the 5 Foods That Boost Your Testosterone.

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