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What is the best treatment for PSA?

mayoclinic.org - Psoriatic arthritis - Diagnosis and treatment - Mayo Clinic

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Diagnosis

During the exam, your doctor might:

Examine your joints for signs of swelling or tenderness

Check your fingernails for pitting, flaking and other abnormalities

Press on the soles of your feet and around your heels for to check for tender areas No single test can confirm a diagnosis of psoriatic arthritis. But some types of tests can rule out other causes of joint pain, such as rheumatoid arthritis or gout.

Imaging tests

X-rays. These can help pinpoint changes in the joints that occur in psoriatic arthritis but not in other arthritic conditions. These can help pinpoint changes in the joints that occur in psoriatic arthritis but not in other arthritic conditions. MRI. This uses radio waves and a strong magnetic field to produce detailed images of both hard and soft tissues in your body. MRI can be used to check for problems with the tendons and ligaments in your feet and lower back.

Laboratory tests

Rheumatoid factor (RF). RF is an antibody that's often present in the blood of people with rheumatoid arthritis but not usually in the blood of people with psoriatic arthritis. This test can help your doctor distinguish between the two conditions. is an antibody that's often present in the blood of people with rheumatoid arthritis but not usually in the blood of people with psoriatic arthritis. This test can help your doctor distinguish between the two conditions. Joint fluid test. Using a needle, the doctor can remove a small sample of fluid from one of your affected joints — often the knee. Uric acid crystals in your joint fluid might indicate that you have gout rather than psoriatic arthritis. It's also possible to have both gout and psoriatic arthritis.

Treatment

No cure exists for psoriatic arthritis. Treatment focuses on controlling inflammation in your affected joints to prevent joint pain and disability and controlling skin involvement. One of the most common treatments are prescription medications called disease-modifying antirheumatic drugs (DMARDs). Treatment will depend on how severe your disease is and what joints are affected. You might have to try different treatments before you find one that brings you relief.

Medications

Drugs used to treat psoriatic arthritis include:

NSAIDs. Nonsteroidal anti-inflammatory drugs (NSAIDs) can relieve pain and reduce inflammation for people with mild psoriatic arthritis. NSAIDs available without a prescription include ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve). Stronger NSAIDs are available by prescription. Side effects can include stomach irritation, heart problems, and liver and kidney damage. Nonsteroidal anti-inflammatory drugs (NSAIDs) can relieve pain and reduce inflammation for people with mild psoriatic arthritis. available without a prescription include ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve). Stronger are available by prescription. Side effects can include stomach irritation, heart problems, and liver and kidney damage. Conventional DMARDs . These drugs can slow the progression of psoriatic arthritis and save joints and other tissues from permanent damage. The most commonly used DMARD is methotrexate (Trexall, Otrexup, others). Others include leflunomide (Arava) and sulfasalazine (Azulfidine). Side effects can include liver damage, bone marrow suppression, and lung inflammation and scarring (fibrosis). Biologic agents. Also known as biologic response modifiers, this class of DMARD targets different pathways of the immune system. Biologic agents include adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), ustekinumab (Stelara), secukinumab (Cosentyx), ixekizumab (Taltz), guselkumab (Tremfya) and abatacept (Orencia). These drugs can increase the risk of infections.

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Also known as biologic response modifiers, this class of targets different pathways of the immune system. Biologic agents include adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), ustekinumab (Stelara), secukinumab (Cosentyx), ixekizumab (Taltz), guselkumab (Tremfya) and abatacept (Orencia). These drugs can increase the risk of infections. Targeted synthetic DMARDs . Tofacitinib (Xeljanz) might be used if conventional DMARDs and biologic agents haven't been effective. Higher doses of tofacitinib can increase the risk of blood clots in the lungs, serious heart-related events and cancer. Tofacitinib (Xeljanz) might be used if conventional and biologic agents haven't been effective. Higher doses of tofacitinib can increase the risk of blood clots in the lungs, serious heart-related events and cancer. Newer oral medication. Apremilast (Otezla) decreases the activity of an enzyme in the body that controls the activity of inflammation within cells. Apremilast is used for people with mild to moderate psoriatic arthritis who do not want or cannot be treated with DMARDs or biologic agents. Potential side effects include diarrhea, nausea and headaches.

Therapies

Physical and occupational therapies might ease pain and make it easier to do everyday tasks. Ask your doctor for referrals. Massage therapy might also offer relief.

Surgical and other procedures

Steroid injections. Injections into an affected joint can reduce inflammation.

Injections into an affected joint can reduce inflammation. Joint replacement surgery. Some joints that have been severely damaged by psoriatic arthritis can be replaced with artificial ones made of metal and plastic.

Lifestyle and home remedies

Protect your joints. Changing how you do everyday tasks can make a difference in how you feel. For example, use gadgets such as jar openers to twist the lids from jars, lift heavy objects with both hands and push doors open with your whole body instead of just your hands. Changing how you do everyday tasks can make a difference in how you feel. For example, use gadgets such as jar openers to twist the lids from jars, lift heavy objects with both hands and push doors open with your whole body instead of just your hands. Maintain a healthy weight. This places less strain on your joints, leading to reduced pain and increased energy and mobility. Losing weight if needed can also help your medications work better. Some psoriatic arthritis medications are less effective in people who are overweight. This places less strain on your joints, leading to reduced pain and increased energy and mobility. Losing weight if needed can also help your medications work better. Some psoriatic arthritis medications are less effective in people who are overweight. Exercise regularly. Exercise can help keep your joints flexible and your muscles strong. Types of exercises that are less stressful on joints include biking, swimming, walking, yoga and tai chi. Exercise can help keep your joints flexible and your muscles strong. Types of exercises that are less stressful on joints include biking, swimming, walking, yoga and tai chi. Stop smoking. Smoking is associated with a higher risk of developing psoriasis and with more-severe symptoms of psoriasis.

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Smoking is associated with a higher risk of developing psoriasis and with more-severe symptoms of psoriasis. Limit alcohol use. Alcohol can decrease the effectiveness of your treatment and increase side effects from some medications, such as methotrexate. Alcohol can decrease the effectiveness of your treatment and increase side effects from some medications, such as methotrexate. Pace yourself. Battling pain and inflammation can leave you exhausted. In addition, some arthritis medications can cause fatigue. Don't stop being active, but rest before you become too tired. Divide exercise or work activities into short segments. Find times to relax throughout the day.

Coping and support

The support of friends and family can make a tremendous difference when you're facing the challenges of psoriatic arthritis. For some people, support groups can offer the same benefits. A counselor or therapist can help you devise coping strategies to reduce your stress levels.

Preparing for your appointment

You're likely to first discuss your signs and symptoms with your family doctor. He or she may refer you to a doctor specializing in the treatment of arthritis and related disorders (rheumatologist).

What you can do

If possible, bring a friend or a family member with you to your appointment to help you remember the information you get.

Make a list of:

Your symptoms and when they began

and when they began Your medical and family history, including any family members with psoriatic arthritis including any family members with psoriatic arthritis All medications, vitamins and other supplements you take, including doses