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This study examined whether combining tadalafil (Cialis) and tamsulosin (Flomax) can reduce both urinary symptoms as well as erectile dysfunction. This treatment combination was safe and effective in reducing urinary symptoms and improving erectile function.

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Posted by Medivizor on Sep 27, 2017 in Benign prostatic hyperplasia |

In a nutshell

Some background

Many men with benign prostatic hyperplasia (BPH) experience both urinary symptoms as well as erectile dysfunction. One report found that 72.2% of men with urinary symptoms due to BPH also had erectile dysfunction. Only 37.7% had urinary symptoms without some form of erectile dysfunction. Tamsulosin is a type of alpha-blocker commonly prescribed for urinary symptoms. It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Tadalafil is a type of phosphodiesterase-5 inhibitor developed for erectile dysfunction. It increases blood flow to the penis and it also helps to relax muscle cells in the bladder and prostate. Both tamsulosin alone and tadalafil alone are commonly used to treat each condition separately. Whether they are safe and effective when combined is still under investigation.

Methods & findings

This study included 510 men with BPH. All men reported urinary symptoms as well as erectile dysfunction. Men were randomly assigned to treatment groups. 153 men were treated with high-dose tamsulosin (0.4 mg) plus tadalafil (5 mg). 164 men were treated with low-dose tamsulosin (0.2 mg) plus tadalafil (5 mg). 162 men were treated with tadalafil alone (5 mg). Treatment outcomes were compared between groups at 12 weeks. Men treated with the 0.4/5 mg combination showed significantly better improvements in urinary symptoms compared to men treated with tadalafil alone. Both groups improved erectile function. The change in urinary symptoms among men treated with the 0.2/5 mg combination was not superior when compared to tadalafil alone. No significant difference in the rate of side effects was observed between groups. 14.11% of men treated with the 0.4/5 mg combination reported side effects. It was 8.43% among men treated with the 0.2/5 mg combination and 5.85% in the group receiving tadalafil alone. Common side effects included headache, nasal congestion, and flushing. Only 0.6 and 1.8% of men reported serious side effects.

The bottom line

This study concluded that the combination of 0.4 mg of tamsulosin and 5 mg of tadalafil reduced urinary symptoms as well as erectile dysfunction safely and effectively in men with BPH.

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How can I make my prostate stronger?

8 Tips for Better Prostate Health Maintain a healthy weight. Obesity is linked to several prostate health issues, including prostate cancer. ... Eat more vegetables. ... Reduce consumption of red meat. ... Know your risk and get tested. ... Exercise regularly. ... Hydrate daily. ... Manage stress. ... Stop smoking.

healthmatters.nyp.org - How To Improve Your Prostate Health

In the U.S., about 1 in 9 men will be diagnosed with prostate cancer during his lifetime. “After skin cancer, prostate cancer is the most common cancer among American men, but this disease can be prevented with simple lifestyle changes or detected early,” says Dr. Gerald Wang, chief of urology at NewYork-Presbyterian Queens and assistant professor of clinical urology at Weill Cornell Medicine. “An adult male who follows dietary guidelines, schedules regular checkups, and receives recommended screenings can live a longer and healthier life.” To raise awareness about preventable conditions among men, Dr. Wang offers eight tips for a healthier prostate:

1. Maintain a healthy weight.

Obesity is linked to several prostate health issues, including prostate cancer. A balanced diet and consistent exercise are important for a healthy prostate and maintaining a healthy weight.

2. Eat more vegetables.

A diet rich in green, leafy vegetables is important for a healthy prostate. Vitamins and antioxidants found in vegetables keep you and your prostate healthy. Try adding lettuce (romaine is among the most nutritious varieties), spinach, kale, and broccoli to your meals each day.

3. Reduce consumption of red meat.

Heavy consumption of red meat has been associated with PhIP, a chemical compound released when red meat is charred, which can cause an increased risk of prostate cancer. By eating red meat only on special occasions, you can reduce your risk.

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