Photo: Jill Burrow

What does prostate cancer spread first?

In theory, prostate cancer cells can spread anywhere in the body. In practice, though, prostate cancer metastasis occurs most often in the lymph nodes and the bones. Prostate cancer metastasis occurs when cells break away from the tumor in the prostate.

mayoclinic.org - Prostate cancer metastasis: Where does prostate cancer spread?

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I'm concerned about prostate cancer metastasis. Where can prostate cancer spread? Answer From Karthik Giridhar, M.D. In theory, prostate cancer cells can spread anywhere in the body. In practice, though, prostate cancer metastasis occurs most often in the lymph nodes and the bones. Prostate cancer metastasis occurs when cells break away from the tumor in the prostate. The cancer cells can travel through the lymphatic system or the bloodstream to other areas of the body.

More commonly prostate cancer metastasis can occur in the:

Bones

Lymph nodes

Lungs

Liver

Rare locations of prostate cancer metastasis include:

Brain

Breasts

Eyes

Kidneys

Muscles

Pancreas

Salivary glands

Spleen

If you've been diagnosed with prostate cancer and you're concerned about prostate cancer metastasis, talk with your doctor about your risk of prostate cancer metastasis and your treatment options.

With Karthik Giridhar, M.D.

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Can you feel bone metastases?

Bone metastasis can cause pain and broken bones. With rare exceptions, cancer that has spread to the bones can't be cured. Treatments can help reduce pain and other symptoms of bone metastases.

mayoclinic.org - Bone metastasis - Symptoms and causes - Mayo Clinic

Overview

Bone metastasis occurs when cancer cells spread from their original site to a bone. Nearly all types of cancer can spread (metastasize) to the bones. But some types of cancer are particularly likely to spread to bone, including breast cancer and prostate cancer. Bone metastasis can occur in any bone but more commonly occurs in the spine, pelvis and thigh. Bone metastasis may be the first sign that you have cancer, or bone metastasis may occur years after cancer treatment. Bone metastasis can cause pain and broken bones. With rare exceptions, cancer that has spread to the bones can't be cured. Treatments can help reduce pain and other symptoms of bone metastases.

Symptoms

Sometimes, bone metastasis causes no signs and symptoms.

When it does occur, signs and symptoms of bone metastasis include:

Bone pain

Broken bones

Urinary incontinence

Bowel incontinence

Weakness in the legs or arms

High levels of calcium in the blood (hypercalcemia), which can cause nausea, vomiting, constipation and confusion

When to see a doctor

If you experience persistent signs and symptoms that worry you, make an appointment with your doctor. If you've been treated for cancer in the past, tell your doctor about your medical history and that you're concerned about your signs and symptoms.

Causes

Bone metastasis occurs when cancer cells break away from the original tumor and spread to the bones, where they begin to multiply. Doctors aren't sure what causes some cancers to spread. And it's not clear why some cancers travel to the bones rather than to other common sites for metastasis, such as the liver.

Risk factors

Virtually any type of cancer can spread to the bones, but the cancers most likely to cause bone metastasis include:

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