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What does L-arginine do for a man?

It is necessary for making proteins and is commonly used for circulation. L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body.

webmd.com - L-ARGININE - Uses, Side Effects, and More - WebMD
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Jude, E. B., Dang, C., and Boulton, A. J. Effect of L-arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus: a double-blind, placebo-controlled study. Diabet.Med. 2010;27(1):113-116. View abstract. Kato, G. J. and Gladwin, M. T. Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA 12-10-2008;300(22):2638-2646. View abstract. Kato, G. J., Wang, Z., Machado, R. F., Blackwelder, W. C., Taylor, J. G., and Hazen, S. L. Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. Br J Haematol. 2009;145(4):506-513. View abstract. Kawano, H., Motoyama, T., Hirai, N., Kugiyama, K., Yasue, H., and Ogawa, H. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 2002;161(2):375-380. View abstract. Kernohan, A. F., McIntyre, M., Hughes, D. M., Tam, S. W., Worcel, M., and Reid, J. L. An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. Br J Clin.Pharmacol. 2005;59(1):85-93. View abstract. Khan, F. and Belch, J. J. Skin blood flow in patients with systemic sclerosis and Raynaud's phenomenon: effects of oral L-arginine supplementation. J Rheumatol. 1999;26(11):2389-2394. View abstract. Khan, F., Litchfield, S. J., McLaren, M., Veale, D. J., Littleford, R. C., and Belch, J. J. Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum. 1997;40(2):352-357. View abstract. Kimber, J., Watson, L., and Mathias, C. J. Cardiovascular and neurohormonal responses to i. v. l-arginine in two groups with primary autonomic failure. J Neurol. 2001;248(12):1036-1041. View abstract. Kirk, S. J., Hurson, M., Regan, M. C., Holt, D. R., Wasserkrug, H. L., and Barbul, A. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993;114(2):155-159. View abstract. Kiziltepe, U., Tunctan, B., Eyileten, Z. B., Sirlak, M., Arikbuku, M., Tasoz, R., Uysalel, A., and Ozyurda, U. Efficiency of L-arginine enriched cardioplegia and non-cardioplegic reperfusion in ischemic hearts. Int.J Cardiol 2004;97(1):93-100. View abstract. Klek, S., Kulig, J., Sierzega, M., Szczepanek, K., Szybinski, P., Scislo, L., Walewska, E., Kubisz, A., and Szczepanik, A. M. Standard and immunomodulating enteral nutrition in patients after extended gastrointestinal surgery--a prospective, randomized, controlled clinical trial. Clin.Nutr 2008;27(4):504-512. View abstract. Klek, S., Kulig, J., Sierzega, M., Szybinski, P., Szczepanek, K., Kubisz, A., Kowalczyk, T., Gach, T., Pach, R., and Szczepanik, A. M. The impact of immunostimulating nutrition on infectious complications after upper gastrointestinal surgery: a prospective, randomized, clinical trial. Ann.Surg. 2008;248(2):212-220. View abstract. Knechtle, B. and Bosch, A. The influence of arginine supplementation on performance and metabolism in athletes. INTERNATIONAL SPORTMED JOURNAL 2008;9(1):22-31. Kobayashi, N., Nakamura, M., and Hiramori, K. Effects of infusion of L-arginine on exercise-induced myocardial ischemic ST-segment changes and capacity to exercise of patients with stable angina pectoris. Coron.Artery Dis 1999;10(5):321-326. View abstract.

Koga, Y. [L-arginine therapy on MELAS]. Rinsho Shinkeigaku 2008;48(11):1010-1012. View abstract.

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Modolell, M., Choi, B. S., Ryan, R. O., Hancock, M., Titus, R. G., Abebe, T., Hailu, A., Muller, I., Rogers, M. E., Bangham, C. R., Munder, M., and Kropf, P. Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis. PLoS.Negl.Trop.Dis 2009;3(7):e480. View abstract. Morgante, G., Scolaro, V., Tosti, C., Di, Sabatino A., Piomboni, P., and De, Leo, V. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. Minerva Urol.Nefrol. 2010;62(3):213-218. View abstract. Morris, C. R., Kuypers, F. A., Larkin, S., Sweeters, N., Simon, J., Vichinsky, E. P., and Styles, L. A. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. 2000;111(2):498-500. View abstract. Mou, J., Fang, H., Jing, F., Wang, Q., Liu, Y., Zhu, H., Shang, L., Wang, X., and Xu, W. Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorg.Med.Chem. 7-1-2009;17(13):4666-4673. View abstract. Moutaouakil, F., El, Otmani H., Fadel, H., Sefrioui, F., and Slassi, I. [l-arginine efficiency in MELAS syndrome. A case report]. Rev.Neurol.(Paris) 2009;165(5):482-485. View abstract. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir.Crit Care Med. 2001;163(4):887-891. View abstract. Napoli, C., Farzati, B., Sica, V., Iannuzzi, E., Coppola, G., Silvestroni, A., Balestrieri, M. L., Florio, A., and Matarazzo, A. Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia. Eur.J Cardiovasc.Prev.Rehabil. 2008;15(6):709-718. View abstract. Nathoo, S., Delgado, E., Zhang, Y. P., DeVizio, W., Cummins, D., and Mateo, L. R. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in New Jersey, USA. J Clin.Dent. 2009;20(4):123-130. View abstract. Nelson, R. L., Thomas, K., Morgan, J., and Jones, A. Non surgical therapy for anal fissure. Cochrane.Database.Syst.Rev. 2012;2:CD003431. View abstract. Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16(1):23-26. View abstract. Neri, I., Jasonni, V. M., Gori, G. F., Blasi, I., and Facchinetti, F. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Matern.Fetal Neonatal Med. 2006;19(5):277-281. View abstract. Neri, I., Monari, F., Sgarbi, L., Berardi, A., Masellis, G., and Facchinetti, F. L-arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications. J Matern.Fetal Neonatal Med. 2010;23(12):1456-1460. View abstract. Nitenberg, A., Ledoux, S., Attali, J. R., and Valensi, P. [Response of the coronary arteries to cold test and flow velocity increase is improved by deferoxamine but not by L-arginine in diabetic patients]. Arch.Mal Coeur Vaiss. 1997;90(8):1037-1041. View abstract. O'Rourke, D. J., Ryan, S., Salomons, G., Jakobs, C., Monavari, A., and King, M. D. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. Dev.Med.Child Neurol. 2009;51(5):404-407. View abstract. Oka, R. K., Szuba, A., Giacomini, J. C., and Cooke, J. P. A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease. Vasc.Med. 2005;10(4):265-274. View abstract. Okamoto, Y., Okano, K., Izuishi, K., Usuki, H., Wakabayashi, H., and Suzuki, Y. Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg. 2009;33(9):1815-1821. View abstract. Olek, R. A., Ziemann, E., Grzywacz, T., Kujach, S., Luszczyk, M., Antosiewicz, J., and Laskowski, R. A single oral intake of arginine does not affect performance during repeated Wingate anaerobic test. J Sports Med.Phys.Fitness 2010;50(1):52-56. View abstract. Ozbek, M., Erdogan, M., Karadeniz, M., Cetinkalp, S., Ozgen, A. G., Saygili, F., Yilmaz, C., and Tuzun, M. 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Clin.Sci.(Lond) 2005;109(6):523-530. View abstract. Pedrinelli, R., Ebel, M., Catapano, G., Dell'Omo, G., Ducci, M., Del, Chicca M., and Clerico, A. Pressor, renal and endocrine effects of L-arginine in essential hypertensives. Eur.J Clin.Pharmacol. 1995;48(3-4):195-201. View abstract. Petrou, I., Heu, R., Stranick, M., Lavender, S., Zaidel, L., Cummins, D., Sullivan, R. J., Hsueh, C., and Gimzewski, J. K. A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin.Dent. 2009;20(1):23-31. View abstract. Pezza, V., Bernardini, F., Pezza, E., Pezza, B., and Curione, M. Study of supplemental oral l-arginine in hypertensives treated with enalapril + hydrochlorothiazide. Am.J Hypertens. 1998;11(10):1267-1270. View abstract. Piatti, P. M., Monti, L. D., Valsecchi, G., Magni, F., Setola, E., Marchesi, F., Galli-Kienle, M., Pozza, G., and Alberti, K. G. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 2001;24(5):875-880. View abstract. Pryor, J. P., Blandy, J. P., Evans, P., Chaput De Saintonge, D. M., and Usherwood, M. Controlled clinical trial of arginine for infertile men with oligozoospermia. Br J Urol. 1978;50(1):47-50. View abstract. Puiman, P. J., Stoll, B., van Goudoever, J. B., and Burrin, D. G. Enteral arginine does not increase superior mesenteric arterial blood flow but induces mucosal growth in neonatal pigs. J Nutr. 2011;141(1):63-70. View abstract. Quyyumi, A. A. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine. J Am Coll.Cardiol 1998;32(4):904-911. View abstract. Ralph, A. P., Kelly, P. M., and Anstey, N. M. L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol. 2008;16(7):336-344. View abstract. Riso, S., Aluffi, P., Brugnani, M., Farinetti, F., Pia, F., and D'Andrea, F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin.Nutr 2000;19(6):407-412. View abstract. Ruel, M., Beanlands, R. S., Lortie, M., Chan, V., Camack, N., deKemp, R. A., Suuronen, E. J., Rubens, F. D., DaSilva, J. N., Sellke, F. W., Stewart, D. J., and Mesana, T. G. Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial. J Thorac.Cardiovasc.Surg. 2008;135(4):762-70, 770. View abstract. Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35(1):32-37. View abstract. Rytlewski, K., Olszanecki, R., Lauterbach, R., Grzyb, A., and Basta, A. Effects of oral L-arginine on the foetal condition and neonatal outcome in preeclampsia: a preliminary report. Basic Clin.Pharmacol.Toxicol. 2006;99(2):146-152. View abstract. Sakurai, Y., Masui, T., Yoshida, I., Tonomura, S., Shoji, M., Nakamura, Y., Isogaki, J., Uyama, I., Komori, Y., and Ochiai, M. Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy. World J Surg. 2007;31(11):2150-2157. View abstract. Saleh, A. I., Abdel Maksoud, S. M., El-Maraghy, S. A., and Gad, M. Z. Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. J Cardiovasc.Pharmacol.Ther 2011;16(1):53-62. View abstract. Salvatore, P., Casamassimi, A., Sommese, L., Fiorito, C., Ciccodicola, A., Rossiello, R., Avallone, B., Grimaldi, V., Costa, V., Rienzo, M., Colicchio, R., Williams-Ignarro, S., Pagliarulo, C., Prudente, M. 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Schilling, J., Vranjes, N., Fierz, W., Joller, H., Gyurech, D., Ludwig, E., Marathias, K., and Geroulanos, S. Clinical outcome and immunology of postoperative arginine, omega-3 fatty acids, and nucleotide-enriched enteral feeding: a randomized prospective comparison with standard enteral and low calorie/low fat i.v. solutions. Nutrition 1996;12(6):423-429. View abstract. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. View abstract. Schlaich, M. P., Jacobi, J., John, S., Delles, C., Fleischmann, I., and Schmieder, R. E. Is l-arginine infusion an adequate tool to assess endothelium-dependent vasodilation of the human renal vasculature? Clin.Sci.(Lond) 2000;99(4):293-302. View abstract. Schlaich, M. P., Oehmer, S., Schneider, M. P., Delles, C., Schmidt, B. M., and Schmieder, R. E. 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Oral L-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials. Clin.Cardiol 2009;32(11):649-652. View abstract. Sunderland, K. L., Greer, F., and Morales, J. VO2max and ventilatory threshold of trained cyclists are not affected by 28-day L-arginine supplementation. J Strength.Cond.Res 2011;25(3):833-837. View abstract.

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Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer. Eur J Surg 1995;161:115-22. View abstract. Sepandi M, Abbaszadeh S, Qobady S, Taghdir M. Effect of L-Arginine supplementation on lipid profiles and inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;148:104407. View abstract. Shah PS, Shah VS, Kelly LE. Arginine supplementation for prevention of necrotising enterocolitis in preterm infants. Cochrane Database Syst Rev. 2017;4:CD004339. View abstract. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. View abstract. So S, Yamaguchi W, Murabayashi N, Miyano N, Tawara F, Kanayama N. Beneficial effect of l-arginine in women using assisted reproductive technologies: a small-scale randomized controlled trial. Nutr Res. 2020;82:67-73. View abstract. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7. View abstract. Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther 2003;29:207-13.. View abstract. Suzuki I, Sakuraba K, Horiike T, et al. A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol 2019;119(5):1075-84. View abstract. Takano H, Lim HB, Miyabara Y, et al. Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice. J Pharmacol Exp Ther 1998;286:767-71. View abstract. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9. View abstract. Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 2001;358:696-701. View abstract. Vadillo-Ortega F, Perichart-Perera O, Espino S, et al. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011 May 19;342:d2901. View abstract. Venho B, Voutilainen S, Valkonen VP, et al. Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2002;76:359-64.. View abstract. Wada N, Kurokawa Y, Tanaka K, et al. Perioperative nutritional support with beta-hydroxy-beta-methylbutyrate, arginine, and glutamine in surgery for abdominal malignancies. Wounds 2018;30(9):251-6. View abstract. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. View abstract. Wang R, Ghahary A, Shen YJ, et al. Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms. J Invest Dermatol 1996;106:419-27. View abstract.

Watanabe G, Tomiyama

webmd.com - L-ARGININE - Uses, Side Effects, and More - WebMD
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