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May help boost testosterone and increase fertility in men The ashwagandha treatment was associated with an 18% greater increase in DHEA-S, a sex hormone involved in testosterone production. Participants who took the herb also had a 14.7% greater increase in testosterone than those who took the placebo ( 14 ).
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Read More »Ashwagandha is one of the most important herbs in Ayurveda, which is a traditional form of alternative medicine based on Indian principles of natural healing. People have used ashwagandha for thousands of years to relieve stress, increase energy levels, and improve concentration ( 1 ). “Ashwagandha” is Sanskrit for “smell of the horse,” which refers to both the herb’s scent and its potential ability to increase strength ( 2 ). Its botanical name is Withania somnifera, and it’s also known by several other names, including “Indian ginseng” and “winter cherry.” The ashwagandha plant is a small shrub with yellow flowers that’s native to India and Southeast Asia. Extracts or powder from the plant’s root or leaves are used to treat a variety of conditions, including anxiety and fertility issues ( 3 ). Here are 9 potential benefits of ashwagandha, based on research. 1. May help reduce stress and anxiety Ashwagandha is perhaps best known for its ability to reduce stress. It’s classified as an adaptogen, a substance that helps the body cope with stress. Ashwagandha appears to help control mediators of stress, including heat shock proteins (Hsp70), cortisol, and stress-activated c-Jun N-terminal protein kinase (JNK-1) ( 4 ). It also reduces the activity of the hypothalamic-pituitary-adrenal (HPA) axis, a system in your body that regulates the stress response ( 4 , 5 ). Several studies have shown that ashwagandha supplements may help relieve stress and anxiety. In a small study with 58 participants, those who took 250 or 600 mg of ashwagandha extract for 8 weeks had significantly reduced perceived stress and levels of the stress hormone cortisol compared with those who took a placebo. What’s more, the participants who took the ashwagandha supplements experienced significant improvements in sleep quality compared with the placebo group ( 4 ). Another study in 60 people found that those who took 240 mg of ashwagandha extract per day for 60 days had significant reductions in anxiety compared with those who received a placebo treatment ( 5 ). Thus, early research suggests ashwagandha may be a helpful supplement for stress and anxiety. However, a recent review of studies concluded that there’s not enough evidence to form a consensus on the most appropriate dosage and form of ashwagandha for treating stress-related neuropsychiatric disorders such as anxiety ( 6 ). Summary Ashwagandha may be effective for reducing stress and anxiety symptoms. However, more research is needed to form a consensus on appropriate forms and dosing to address stress and stress-related disorders. 2. May benefit athletic performance Research has shown that ashwagandha may have beneficial effects on athletic performance and may be a worthwhile supplement for athletes. One analysis of research included 12 studies in men and women who took ashwagandha doses between 120 mg and 1,250 mg per day. The results suggest the herb may enhance physical performance, including strength and oxygen use during exercise ( 7 ). An analysis of five studies found that taking ashwagandha significantly enhanced maximum oxygen consumption (VO 2 max) in healthy adults and athletes ( 8 ). VO 2 max is the maximum amount of oxygen a person can use during intense activity. It’s a measurement of heart and lung fitness. Having optimal VO 2 max is important for athletes and nonathletes alike. Low VO 2 max is associated with increased mortality risk, while higher VO 2 max is associated with a lower risk of heart disease ( 8 ). Additionally, ashwagandha may help increase muscle strength. In one study, male participants who took 600 mg of ashwagandha per day and participated in resistance training for 8 weeks had significantly greater gains in muscle strength and size compared with a placebo group ( 9 ). Summary Ashwagandha may help improve measures of physical performance in athletes and healthy adults, including VO 2 max and strength. 3. May reduce symptoms of some mental health conditions Some evidence suggests that ashwagandha may help reduce symptoms of other mental health conditions, including depression, in certain populations. In one study, researchers looked at the effects of ashwagandha in 66 people with schizophrenia who were experiencing depression and anxiety. They found that participants who took 1,000 mg of ashwagandha extract daily for 12 weeks had greater reductions in depression and anxiety than those who took a placebo ( 10 ). What’s more, findings from another study suggest that taking ashwagandha may help improve total symptoms and perceived stress in people with schizophrenia ( 11 ). Limited research from 2013 also suggests that ashwagandha may help improve cognitive impairment in people with bipolar disorder. However, more research is needed ( 12 ). Additionally, a study from 2012 found that stressed adults who took 600 mg of ashwagandha extract per day for 60 days reported a 77% reduction in symptoms of depression, while the placebo group reported a 5% reduction ( 13 ). However, only one of the participants in this study had a history of depression, so the relevance of the results is unclear. Although some findings suggest that ashwagandha may have some antidepressant effects in certain people, you should not try to use it as a substitute for antidepressant medication. If you’re experiencing symptoms of depression, talk with a healthcare professional so you can get any help or treatment you may need. Summary The limited research available suggests that ashwagandha may help reduce symptoms of depression and benefit people with some mental health conditions. However, more research is needed. 4. May help boost testosterone and increase fertility in men Ashwagandha supplements have been shown in some studies to benefit male fertility and increase testosterone levels. In one study, 43 overweight men ages 40–70 who had mild fatigue took tablets containing ashwagandha extract or a placebo daily for 8 weeks. The ashwagandha treatment was associated with an 18% greater increase in DHEA-S, a sex hormone involved in testosterone production. Participants who took the herb also had a 14.7% greater increase in testosterone than those who took the placebo ( 14 ). Additionally, a review of four studies found that ashwagandha treatment significantly increased sperm concentration, semen volume, and sperm motility in men with low sperm count. It also increased sperm concentration and motility in men with normal sperm count ( 15 ). However, the researchers concluded that there’s currently not enough data to confirm the potential benefits of ashwagandha for male fertility and that more high quality studies are needed ( 15 ). Summary Ashwagandha may help increase testosterone levels and may have some potential benefits for male fertility. However, more research is needed.
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Read More »5. May reduce blood sugar levels Limited evidence suggests that ashwagandha may have some benefits for people with diabetes or high blood sugar levels. A review of 24 studies, including 5 clinical studies in people with diabetes, found that treatment with ashwagandha significantly reduced blood sugar, hemoglobin A1c (HbA1c), insulin, blood lipids, and oxidative stress markers ( 16 ). It’s believed that certain compounds within ashwagandha, including one called withaferin A (WA), have powerful antidiabetic activity and may help stimulate your cells to take in glucose from your bloodstream ( 17 ). However, research is limited at this time, and more well-designed studies are needed. Summary Limited evidence suggests that ashwagandha may reduce blood sugar levels through its effects on insulin secretion and cells’ ability to absorb glucose from the bloodstream. 6. May reduce inflammation Ashwagandha contains compounds, including WA, that may help reduce inflammation in the body ( 18 ). Researchers have found that WA targets inflammatory pathways in the body, including signal molecules called nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2). Animal studies have shown that WA may also help reduce levels of inflammatory proteins such as interleukin-10 (IL-10) ( 18 ). There’s some evidence that ashwagandha may help reduce inflammatory markers in humans too. In one study from 2008, adults experiencing stress took ashwagandha extract for 60 days. As a result, they had significant reductions in C-reactive protein — an inflammatory marker — compared with those who consumed a placebo (19). In another study, researchers gave people with COVID-19 an Ayurvedic drug containing 0.5 grams of ashwagandha and other herbs twice per day for 7 days. This reduced participants’ levels of inflammatory markers CRP, IL-6, and TNF-α compared with a placebo ( 20 ). The treatment formulation also contained: 1 gram of giloy ghanvati (Tinospora cordifolia)
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Learn More »9. Relatively safe and widely available Ashwagandha is a safe supplement for most people, although its long-term effects are unknown. A review of 69 studies found that ashwagandha root appears to be safe and effective for managing certain health conditions, including stress, anxiety, and insomnia ( 1 ). One study in 80 healthy men and women showed that taking 600 mg of ashwagandha daily for 8 weeks was safe and did not cause any adverse health effects in participants ( 25 ). However, certain people should not take it. For example, pregnant people should avoid it because it may cause pregnancy loss if used in high doses (26). Also, those with hormone-sensitive prostate cancer and those taking certain medications, such as benzodiazepines, anticonvulsants, or barbiturates, should avoid taking ashwagandha (26). Some side effects have been reported in people taking ashwagandha supplements, including upper gastrointestinal discomfort, drowsiness, and diarrhea (26). Additionally, ashwagandha may affect the thyroid, so those with thyroid disease should check with a healthcare professional before taking it ( 27 ). Dosing recommendations for ashwagandha vary. For example, doses ranging from 250–1,250 mg per day have been shown to be effective for different conditions. Consult a healthcare professional if you have questions regarding ashwagandha dosing. Research findings suggest that ashwagandha’s effects aren’t immediate, so keep in mind that you may have to take it for several months before you start noticing its effects. You can take ashwagandha in many ways, in either a single dose or multiple doses per day. And you can take it either with meals or on an empty stomach. Several supplement manufacturers produce it and various retailers sell it, including health food stores and vitamin shops. Summary Although ashwagandha is safe for most people, it’s not safe for everyone. It’s important to check with a healthcare professional before taking ashwagandha.
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