What can lower free PSA?

Men who are overweight, particularly those who are very obese, tend to have lower free PSA levels. Smoking. One study found that men who smoke or used to smoke have lower free PSA levels than those who never did.

webmd.com - What Causes Low Free PSA Levels? - WebMD

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Symptoms of benign prostate enlargement If the prostate becomes enlarged, it can place pressure on the bladder and the urethra, which is the tube...

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Many men are familiar with the routine: During your annual exam, your doctor slips on a glove and feels your prostate. The goal is to check this walnut-sized organ for lumps, hard spots, and other possible signs of cancer. If your doctor finds something that doesn’t feel right, the next step may be a biopsy, which takes a sample of tissue for examination under a microscope. Another part of the screening for prostate cancer may include screening your blood for free prostate-specific antigen or PSA. Talk to your doctor to see if screening is right for you. What Are PSA and Free PSA? PSA a protein that makes semen more liquid-like. This makes it easier for sperm to reach a woman’s egg during sex. It’s normal for a small bit of PSA to get into your bloodstream. If you have cancer or other prostate problems, more PSA will circulate in your blood. But checking for PSA levels alone often can lead to false positive results for prostate cancer. Three out of 4 men with high overall PSA levels turn out to be cancer-free. A more accurate way to predict prostate cancer is to also look for a second form of PSA called free PSA. The name comes from the fact that free PSAs flow through your blood solo, without being attached to other proteins as are regular PSAs. The ratio of your free PSAs to your overall PSA levels can give a better picture about your prostate cancer risk. The amount of free PSA is lower in men who have prostate cancer. That’s the opposite of total PSA, high levels of which can be a sign of cancer. In two men with identical levels of total PSA, the one who has a lower amount of free PSA is more likely to have cancer. One study found that free PSA levels as a percentage of total PSA may be the best way to diagnose prostate cancer.

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What PSA level is cancerous?

There is no specific normal or abnormal level of PSA in the blood. In the past, PSA levels of 4.0 ng/mL and lower were considered normal. However, some individuals with PSA levels below 4.0 ng/mL have prostate cancer and many with higher PSA levels between 4 and 10 ng/mL do not have prostate cancer (1).

cancer.gov - Prostate-Specific Antigen (PSA) Test - NCI

Prostate-specific antigen, or PSA, is a protein produced by normal, as well as malignant, cells of the prostate gland. The PSA test measures the level of PSA in the blood. For this test, a blood sample is sent to a laboratory for analysis. The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood. The blood level of PSA is often elevated in people with prostate cancer, and the PSA test was originally approved by the FDA in 1986 to monitor the progression of prostate cancer in men who had already been diagnosed with the disease. In 1994, FDA approved the PSA test to be used in conjunction with a digital rectal exam (DRE) to aid in the detection of prostate cancer in men 50 years and older. Until about 2008, many doctors and professional organizations had encouraged yearly PSA screening for prostate cancer beginning at age 50. PSA testing (along with a DRE) is also often used by health care providers for individuals who report prostate symptoms to help determine the nature of the problem. In addition to prostate cancer, several benign (not cancerous) conditions can cause a person’s PSA level to rise, particularly prostatitis (inflammation of the prostate) and benign prostatic hyperplasia (BPH) (enlargement of the prostate). There is no evidence that either condition leads to prostate cancer, but someone can have one or both of these conditions and develop prostate cancer as well.

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