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What are the symptoms of stage 1 lymphoma?

Symptoms Painless swelling of lymph nodes in your neck, armpits or groin. Persistent fatigue. Fever. Night sweats. Losing weight without trying. Severe itching. Pain in your lymph nodes after drinking alcohol.

mayoclinic.org - Hodgkin's lymphoma (Hodgkin's disease) - Symptoms and causes

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Overview

Parts of the immune system Open pop-up dialog box Close Parts of the immune system Parts of the immune system The lymphatic system is part of the body's immune system, which protects against infection and disease. The lymphatic system includes the spleen, thymus, lymph nodes and lymph channels, as well as the tonsils and adenoids. Lymph node clusters Open pop-up dialog box Close Lymph node clusters Lymph node clusters Lymph nodes are bean-sized collections of cells called lymphocytes. Hundreds of these nodes cluster throughout the lymphatic system, for example, near the knee, groin, neck and armpits. The nodes are connected by a network of lymphatic vessels. Hodgkin's lymphoma is a type of cancer that affects the lymphatic system, which is part of the body's germ-fighting immune system. In Hodgkin's lymphoma, white blood cells called lymphocytes grow out of control, causing swollen lymph nodes and growths throughout the body. Hodgkin's lymphoma, which used to be called Hodgkin's disease, is one of two general categories of lymphoma. The other is non-Hodgkin's lymphoma. Advances in diagnosis and treatment of Hodgkin's lymphoma have helped give people with this disease the chance for a full recovery. The prognosis continues to improve for people with Hodgkin's lymphoma.

Types

Symptoms

Swollen lymph nodes Open pop-up dialog box Close Swollen lymph nodes Swollen lymph nodes One of the most common places to find swollen lymph nodes is in the neck. The inset shows three swollen lymph nodes below the lower jaw.

Signs and symptoms of Hodgkin's lymphoma may include:

Painless swelling of lymph nodes in your neck, armpits or groin

Persistent fatigue

Fever

Night sweats

Losing weight without trying

Severe itching

Pain in your lymph nodes after drinking alcohol

When to see a doctor

Make an appointment with your health care provider if you have any persistent signs or symptoms that worry you. There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. Get Mayo Clinic cancer expertise delivered to your inbox. Subscribe for free and receive an in-depth guide to coping with cancer, plus helpful information on how to get a second opinion. You can unsubscribe at any time. I would like to learn more about Up-to-date cancer news & research Mayo Clinic cancer care & management options ErrorSelect a topic Email address ErrorEmail field is required ErrorInclude a valid email address Subscribe Learn more about Mayo Clinic’s use of data. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Thank you for subscribing Your in-depth coping with cancer guide will be in your inbox shortly. You will also receive emails from Mayo Clinic on the latest about cancer news, research, and care. If you don’t receive our email within 5 minutes, check your SPAM folder, then contact us at newsletters@mayoclinic.com. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry

Causes

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Doctors aren't sure what causes Hodgkin's lymphoma. They know that it begins when infection-fighting white blood cells called lymphocytes develop changes in their DNA. A cell's DNA contains the instructions that tell a cell what to do. The DNA changes tell the cells to multiply rapidly and to continue living when other cells would naturally die. The lymphoma cells attract many healthy immune system cells to protect them and help them grow. The extra cells crowd into the lymph nodes and cause swelling and other Hodgkin's lymphoma signs and symptoms. There are multiple types of Hodgkin's lymphoma. Your type is based on the characteristics of the cells involved in your disease and their behavior. The type of lymphoma you have helps determines your treatment options.

Classical Hodgkin's lymphoma

Classical Hodgkin's lymphoma is the more common type of this disease. People diagnosed with this type have large lymphoma cells called Reed-Sternberg cells in their lymph nodes.

Subtypes of classical Hodgkin's lymphoma include:

Nodular sclerosis Hodgkin's lymphoma

Mixed cellularity Hodgkin's lymphoma

Lymphocyte-depleted Hodgkin's lymphoma

Lymphocyte-rich Hodgkin's lymphoma

Nodular lymphocyte-predominant Hodgkin's lymphoma

This much rarer type of Hodgkin's lymphoma involves lymphoma cells that are sometimes called popcorn cells because of their appearance. Nodular lymphocyte-predominant Hodgkin's lymphoma is usually diagnosed at an early stage and may require less intensive treatments compared to the classical type of the disease.

Risk factors

Factors that can increase the risk of Hodgkin's lymphoma include:

mayoclinic.org - Hodgkin's lymphoma (Hodgkin's disease) - Symptoms and causes

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