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What are the side effects of pumpkin seeds?

It is possibly safe to take pumpkin seed or pumpkin seed oil in medicinal amounts. Side effects from pumpkin products are rare, but might include stomach discomfort, diarrhea, and nausea. It might also cause itching, rash, and allergic reactions in some people.

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Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. View abstract. Carbin BE, Larsson B, Lindahl O. Treatment of benign prostatic hyperplasia with phytosterols. Br J Urol 1990;66:639-41. View abstract. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. View abstract. Coulson S, Rao A, Beck SL, Steels E, Gramotnev H, Vitetta L. A phase II randomised double-blind placebo-controlled clinical trial investigating the efficacy and safety of ProstateEZE Max: a herbal medicine preparation for the management of symptoms of benign prostatic hypertrophy. Complement Ther Med 2013;21(3):172-9. View abstract. De Bellis L, Gonzali S, Alpi A, et al. Purification and characterization of a novel pumpkin short-chain acyl-coenzyme A oxidase with structural similarity to acyl-coenzyme A dehydrogenases. Plant Physiol 2000;123:327-34. View abstract. Durante M, Lenucci MS, Mita G. Supercritical carbon dioxide extraction of carotenoids from pumpkin (Cucurbita spp.): a review. Int J Mol Sci 2014;15(4):6725-40. View abstract. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. Friederich M, Theurer C, Schiebel-Schlosser G. [Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients]. Forsch Komplementarmed Klass Naturheilkd 2000;7:200-4. View abstract. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. View abstract. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. View abstract. Ibrahim IM, Hasan MS, Elsabaa KI, Elsaie ML. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. J Cosmet Dermatol 2021 Feb 5. doi: 10.1111/jocd.13976. View abstract. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. View abstract. Medjakovic S, Hobiger S, Ardjomand-Woelkart K, Bucar F, Jungbauer A. Pumpkin seed extract: cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors. Fitoterapia 2016;110:150-6. View abstract. Shirvan MK, Mahboob MR, Masuminia M, Mohammadi S. Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. J Pak Med Assoc 2014;64(6):683-5. View abstract. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95. View abstract. Younis YM, Ghirmay S, al-Shihry SS. African Cucurbita pepo L.: properties of seed and variability in fatty acid composition of seed oil. Phytochemistry 2000;54:71-5. View abstract. Zerafatjou N, Amirzargar M, Biglarkhani M, Shobeirian F, Zoghi G. Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial. BMC Urol 2021;21(1):147. View abstract. Zhang X, Ouyang JZ, Zhang YS, et al. Effect of the extracts of pumpkin seeds on the urodynamics of rabbits: an experimental study. J Tongji Med Univ 1994;14:235-8. View abstract.

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