Prostate Restored
Prostate Restored
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The results of this trial are the first firm evidence that cranberries may improve the prostate health of men at risk of prostate disease leading to a number of medical complications including prostate cancer.
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Cranberry juice is most well-known for the beneficial effect it can have on symptoms of a urinary tract infection; however, it may also be...
Read More »Introduction and Objectives Cranberry products are frequently used in the prevention of urinary tract infection. The objective of this study was to evaluate the efficacy and tolerability of cranberry fruit powder in men at risk of prostate disease with lower urinary tract symptoms (LUTS), negative prostate biopsies and clinically confirmed chronic nonbacterial prostatitis. Material and Methods Forty two participants were randomized to receive either 500 mg of dried powdered cranberries (n = 21, Cranberry group) 3 times daily or no treatment for six months (n = 21, Control group). At baseline both groups had similar clinical and demographic characteristics. They were evaluated using physical examination, the International Prostate Symptom score (IPSS), Quality of Life Score (QoL), International Index of Erectile Function (IIEF-5), basic laboratory parameters, hematology, selenium, testosterone, prostate specific antigen, antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound estimated postvoid residual urine volume at baseline and at 3 and 6 months. Urine ex vivo antiadherence activity was determined on the last day of study. Results In contrast to the Control group, patients in Cranberry group had statistically significant improvement in IPSS, QoL, IIEF-5, urination parameters including voiding parameters: rate of urine flow (Q max ), average flow (Q ave ), total volume (V) and postvoid residual urine volume (RV), lower PSA tot level on 180 day of the study. There was no influence on blood testosterone levels and no adverse events recorded. No improvement was found in the control group. Conclusions The results of this trial are the first firm evidence that cranberries may improve the prostate health of men at risk of prostate disease leading to a number of medical complications including prostate cancer. Article Info Identification DOI: https://doi.org/10.1016/S1569-9056(09)75035-3 Copyright © 2009 European Association of Urology. Published by Elsevier Inc. All rights reserved. ScienceDirect Access this article on ScienceDirect
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Read More »The recommended dosing for UTI prophylaxis is based on the most recent positive randomized controlled trial19 that used one tablet of concentrated cranberry extract (300 to 400 mg) twice daily, or 8 oz of pure unsweetened cranberry juice three times daily.
The first relatively large placebo-controlled studies12,13 assessing efficacy were conducted in elderly women living in long-term care facilities. The findings of these studies12,13 showed that cranberry significantly reduced the frequency of bacteriuria and pyuria, but these were not intention-to-treat analyses. A 1997 study, published as a letter in The Journal of Family Practice,14 used a younger cohort of women and was the first study to use cranberry extract tablets rather than juice. Results showed that the cranberry concentrate was more effective than placebo in reducing the occurrence of UTIs.14 However, only 10 women completed the study.14 Another pair of studies15,16 found cranberry ineffective in decreasing bacteriuria in children with neurogenic bladder requiring intermittent catheterization. A Cochrane Database systematic review,17 citing small sample sizes and the poor quality of available trials, determined that there was no reliable evidence of effectiveness of cranberry in UTI prophylaxis.
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