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How much pleasure is lost after circumcision?

Morris' systematic review carried out in Australia [23] on early MC, with a total of 40,473 men, showed that medical circumcision (MC) does not adversely affect sexual function, sensitivity or pleasure.

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Search strategy and study selection

A non-systematic narrative review was performed using the following search terms: “circumcision”; “children circumcision”; “neonatal circumcision”; “circumcision and sexual dysfunction“; “premature ejaculation (PE)”; and “erectile dysfunction and circumcision”. The search for literature was performed between July 2019 and October 2019 through the electronic databases: PubMed (MEDLINE), WHO/UNAIDS, Google-Scholar, Semantic-Scholar and Research Gate and included articles between 1986 and 2019. After the first revision of the article any updates as of March 30th 2020 were added. Citations and abstracts identified by the search strategy were screened. There were no languages or publication year limitations. Those studies lacking data were not included due to possible limitations or bias. There was no exclusion due to cultural/background differences of the population studied. Randomized controlled trials, meta-analyses, systematic reviews and large studies were the preferable choice if available. Internet searches were performed if necessary to clarify terms or to search relevant information concerning policies. A resume table follows each section including the articles reviewed, aims of the studies, number of patients and outcomes.

Circumcision and PE

PE [5] is one of the most common sexual dysfunction in all men around the world. It is defined by ejaculation occurring within less than 1 min after penetration and its aetiology remains unknown. Many studies have argued a relation between circumcision and PE. One of the hypotheses suggests that PE might be caused by somatic and neurobiological disorders. Evidence suggests a relationship between the higher amount of nerve fibres in redundant prepuce and high sensitivity as a possible cause of PE [6]. In another prospective study post-circumcision penile mucosal cuff length, scar thickness and PE syndrome were evaluated and no association was found when compared to the healthy control group [7]. Most of the studies were carried out in adult population, therefore the impact of MC during infancy in PE it is difficult to evaluate. Based on the results of these studies it is not possible to conclude that circumcision has a correlation with PE as there is not enough evidence. In the prospective study performed by Gao [8] on 998 men, those who had been circumcised reported better ejaculatory control and PE severity than those uncircumcised at 3-, 6-, 9- and 12-months follow-up. In the study performed by Alp et al. [9] the intravaginal ejaculation latency time (IELT) was evaluated. The mean IELT was 104.36- ±66.21 s and 123.56 ± 54.44 s before and after circumcision, respectively. For the individual evaluation of PE, the PE diagnostic tool (PEDT) scores included the following items: perceived control, frequency, minimal stimulation, distress and interpersonal difficulty. The mean scores were 4.26 ± 2.91 before and 2.63 ± 1.82 after circumcision. They concluded that improvements in IELT and PEDT after circumcision were statistically significant. In the systematic review and metanalysis conducted by Yang [10] circumcision status was not associated with PE (OR, 0.90; 95% CI, 0.72–1.13; p = 0.37). Most of the studies and systematic reviews support the evidence favouring a lower prevalence of PE in circumcised males [9, 10, 11]. Whereas Tang and Khoo [11] showed that 50.9% of circumcised men and 28.9% of uncircumcised men suffered from PE (OR, 2.56; 95% CI, 1.44–4.55; p = 0.001), other studies which established that circumcision is associated with PE like Richters et al. evaluate as PE the facility of coming to an orgasm [12]. It happened on 26% of circumcision men and 22% of control group (OR, 1.28; 95% CI, 1.15–1.42; p < 0.0001). However, the difference was not statistically significant after adjustment (p = 0.11). Frisch et al. [13] conducted a cross-sectional study in Denmark. The proportion of PE among circumcised men and uncircumcised group was 59% and 61%, respectively, (OR, 0.92 95% CI 0.60–1.41). In the case control study from Aydogmus et al. [14] PE was observed in 32% of the patients in the preoperative study group, 22% of the postoperative and 23% of controls. Their results showed no significant difference between any of these groups for PEDT and IELT scores, neither for PE. However, a significant improvement was seen when pre and postoperative values were compared for the three items.

The studies related to “PE and circumcision” are summarized in Table 1.

Table 1 Male circumcision and premature ejaculation. Full size table

Circumcision and male sexual dysfunction

Sexual dysfunction it is defined in the DSM V as an inability for sexual reaction and satisfaction responses during sexual activity. It includes disorders of sexual desire or interest, arousal, orgasm and sexual pain [15]. According to Barlow’s model sexual dysfunction is based on cognitive interference and anxiety [16]. The role of attention and its influence on sexual dysfunction has been studied by Jong [17] and his research suggests that sexual arousal could be facilitated or disrupted by cognitive bias. Thus, an individual suffering a negative self-perception is prompt to drive his/her attention away from the erotic stimuli. This is likely to result in an autonomic nervous system response and consequently creates a negative feedback loop affecting the sexual function. The attitude of men towards their own circumcision was shown to be more important in the study carried out by Bossio [18], which explores the relationship between attitude towards one’s circumcision status, timing of one’s circumcision and sexual correlates. After studying 811 men (367 circumcised as newborns, 107 during childhood, 47 as adults and 290 uncirumised) they concluded that negative attitude towards one’s circumcision is related to worse body image and sexual functioning, and not the circumcision status of men. Few studies have investigated the effect of circumcision on body image and social phobia [14]. In the previous mentioned study from Aydogmus et al. [14] self-body image and social anxiety were studied through Body Cathexis Scale (BCS), Liebowitz Social Anxiety Scale (LSAS). After circumcision a significant reduction was seen for both BCS and LSAS. This study was carried out among Turkish men, however the conclusions showed the importance of social anxiety and the correspondingly negative effects of it on sexual function and satisfaction. The sample described in their study did not experience any worsening of their PEDT scores, IELT values or PE. In addition, when evaluating BCS and LSAS items on sexuality, circumcision improved sexual satisfaction in the studied group. Therefore, this study supports the evidence that men’s attitude towards circumcision is a determinant factor for sexual satisfaction, whereas its negative impact in PE or PEDT scores is not yet consistently proven.

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Circumcision in the infancy and male sexual dysfunction

The possible effect of infant circumcision on male sexual dysfunction cannot be determined directly and it is still in debate. It can be inferred from adult male sexual function. Hypothetically childhood circumcision could lead to histological changes such as keratinization of the glans surface, diminishing sensitivity and consequently sexual excitability. It has also been suggested that lesions of the prepuce could cause atrophy of the brain circuitry leading to lower excitability [19]. However, a recent systematic review of histological and anatomical data on sensory receptors in the penis, which includes also those changes that appear in puberty concludes that nerve endings related to sexual pleasure reside in the glans and the foreskin have no role in sexual sensation [20]. Meissner corpuscles of the foreskin had unlikely a role in erotic sensation as their density decreases at the age when sexual activity gets higher [20]. Free nerve endings showed no statistic correlation with sexual response and tactile sensitivity of the glans, as the later decreases with sexual arousal and it is not linked to sexual sensation. Hypotheses on higher penile sexual sensation after circumcision correlate to the bigger surface accessible of genital corpuscles after the removal of the foreskin, based on their distribution in the glans. Furthermore, vibrational and thermal sensitivity during intercourse are perceived as a reward mechanism and neither of them is related to circumcision status. In the prospective study carried out by Aydur [21] they reported no relationship between circumcision age and overall male sexual function. When comparing subgroups of specific spheres of sexual function, avoidance and communication appeared to be influenced by age at the time of circumision. However, these seem to be very subjective matters related to negative body image perception as previously described. Many studies have proven that MC has no negative effect on sexual function. The RCTs from sub-Saharan Africa carried out by Kigozi [22], showed no statistically significant difference on sexual function after including more than 10,000 men. Aydur et al. [21] could not find any association between age of childhood circumcision and overall sexual function in men between 22 and 44 years old, however as men in Turkey are mostly circumcised in childhood there was no uncircumcised men control group. Morris’ systematic review carried out in Australia [23] on early MC, with a total of 40,473 men, showed that medical circumcision (MC) does not adversely affect sexual function, sensitivity or pleasure. In the Danish study from Shabanzadeh et al. [24] no statistical difference could be found in the outcomes after undergoing non MC, however problems in reaching orgasm increased and ED was reported inconsistently. This systematic review contained 38 studies including two randomised trials. The only differences that they could find in sexual function for circumcised men were decreased PE and increased penile sensitivity. Those men who were circumcised younger were less prone to suffer sexual dysfunction than those circumcised later in life. There is enough literature supporting the fact that childhood circumcision has no negative influence in sexual function per se. A survey carried out in the United Kingdom (AIDS 2015) confirmed these findings also on 6293 men and 8869 women [25]. The studies related to “circumcision in the infancy and male sexual dysfunction” are summarized in Table 2.

Table 2 Circumcision and male sexual function. Full size table

Age of circumcision

There is still a controversial discussion with arguments in favour of early MC over delayed and elective MC at an older age. Using the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) Aydin et al. conducted a prospective study [26] with the objective of analysing sexual dysfunction among circumcised men in different infancy and childhood age groups. Prevalence of sexual dysfunction in overall and specific areas of GRISS showed no statistically significant difference among the three groups. The 3–5 years group showed worse results on the scores of coitus frequency, degree of satisfaction, sensuality and erectile function but no statistically significant differences were found. The 3–5 years age group had the best mean score of ejaculatory function. Only in the avoidance domain was it possible to find statistically significant differences between groups, with lower avoidance in the infantile circumcision group compared to those who underwent circumcision at the age of 3–5 years (P < 0.05). After dividing men into sexually functional and dysfunctional groups and comparing with mean age at the time of circumcision there was no difference in overall sexual function. However, in the communication domain those men sexually dysfunctional were statistically significantly younger. The study of Armagan [27] evaluated the possible negative impact of circumcision during the phallic period (3- to 6-year-old) on psychosexual functions in 302 adult males. No statistical difference was found between the mean total IIEF scores (group-1, phallic period: 25.1 ± 4.8, group-2, non-phallic period: 25.4 ± 4.6, P > 0.005); overall satisfaction was also found to be comparable. The PEDT scores were comparable between both groups (group-1: 8.2 ± 4.8, group- 2: 8.7 ± 5.4, P > 0.05).

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To evaluate psychological status Beck depression scores were performed, which showed no differences between groups (group-1: 10.8 ± 10.4, group-2: 9.8 ± 8.9, P > 0.05). Their results supported that circumcision during the phallic period has no correlation with psychosexual dysfunction in the adulthood. Cuceloglu [26] reported that circumcision performed after 7 years of age could negatively affect PE compared to those who underwent the procedure at an earlier age. The review by Yavuz et al. hypothesized that as circumcision is a part of the community rituals or practices, the child not only won’t perceive it as a threat, but also he would be aware of its significance and the consequences that implies [28]. They advise to perform circumcision at an age when he can make his own decisions. Nevertheless, it needs to be remarked that this study was carried out in a population where circumcision is part of the sociocultural background, thus having a very important role and influence in the perception on body image and sexuality. On the somatosensory level, Bleustein et al. [29] carried out a study using a battery of quantitative somatosensory tests evaluating small to large axon function. After performing a comparative analysis of uncircumcised and neonatally circumcised men, their results showed no significantly differences in the quantitative somatosensory tests of the glans.

The studies related to “age of circumcision” are summarized in Table 3.

Table 3 Age of circumcision and male sexual function. Full size table

Medical benefits of circumcision during childhood

Circumcision is a common procedure performed historically and culturally because of its medical benefits, among many other reasons. Despite its advantages it is still controversial if the benefits outweigh the risks, and if so when it would be the better timing for it. Although there are many arguments in favour of MC, it seems reasonable to question if infant MC offers a true benefit over MC later in life, when the boy can decide for himself. There are few studies comparing the merits of MC at different ages. On the systematic review of the literature by Morris et al. [30], they studied infant MC vs MC in childhood, adolescence and adulthood. They emphasized the benefits of an early circumcision to avoid losing the medical benefits of it. In the first year of life, UTI in males is most common and affects 1–2% of uncircumcised boys compared to 0.1–0.2% of boys who are circumcised [31]. In the study performed by Ellison [32] 5560 boys with uretero-hydronephrosis (UH) and 11,120 healthy boys were identified through a nationwide database and after the multivariate analysis newborn circumcision was associated with a significantly decreased risk of UTI (OR 0.36 [95% confidence interval (CI) 0.29–0.44] for boys with hydronephrosis; OR 0.32 [95% CI 0.21–0.48] for healthy patients). The necessary number to treat to avoid one UTI was 10 for those children with UH compared with 83 in healthy boys. Other medical benefits include reducing the risk of balanitis [30] and it also eliminates the risk of suffering lichen sclerosis, which is diagnosed in up to 40% of foreskins removed for phimosis [33]. Several STIs are also most common in uncircumcised male, including human papillomavirus (HPV) [34] Trichomonas vaginalis [4], Mycoplasma genitalium, [30] syphilis [34] and HIV [35]. Reduced risk of penile cancer and cervical cancer, the latter due to the reduction in HPV transmission are also arguments of many physicians to defend newborn MC as a public health policy [1, 4, 31]. On the other hand, the prevalence of adverse events of MC, in the literature review by the American Association of Pediatry and the Center of Disease Control research of 1.4 million MCs from 2001 to 2010 (93% in newborns) [36], showed that in less than 0.5% of newborn infants there is a complication and these are mostly minor. Meatal stenosis appears in 0.01–1% of males during the follow-up although it is not necessarily related to the procedure itself but to foreskin diseases or as an accidental finding [2]. The studies related to “medical benefits of circumcision during childhood” are summarized in Table 4.

nature.com - Circumcision in childhood and male sexual function: a blessing ... - Nature

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