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In a study published in the Journal of Urology, researchers found that daily intake of 500 mg of dried cranberry powder improved OAB symptoms and patient-reported bladder condition after the 24-week study period, compared with placebo.
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Read More »Daily intake of dried cranberry powder improved some symptoms of overactive bladder (OAB) and the patients’ perception of their bladder condition in adult women, according to a recent study published in the September issue of the Journal of Urology.1 Take Note Overactive bladder is highly prevalent, affecting up to 12% of adults, with a significant impact on the quality of life and physical and psychological health of affected individuals. In a study published in the Journal of Urology, researchers found that daily intake of 500 mg of dried cranberry powder improved OAB symptoms and patient-reported bladder condition after the 24-week study period, compared with placebo. The results from this single-center, randomized, double-blind, placebo-controlled study, conducted by researchers at the Weill Cornell Medical College, New York, showed that daily intake of 500 g of dried cranberry powder decreased daily micturition by 16.4% and urgency episodes by 57.3%, while also improving patient perception of bladder condition by 39.7%.1 The International Continence Society defines OAB as a syndrome that includes urinary urgency, usually accompanied by increased daytime frequency and/or nocturia, with urinary incontinence (OAB-wet) or without (OAB-dry), in the absence of urinary tract infection (UTI) or other detectable disease or pathology.2 OAB is highly prevalent, estimated to affect up to 12% of adults, with a projected cost of $82.6 billion this year in the United States.3,4 Although the joint guidelines for management of OAB published by the American Urological Association/Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction note that OAB is not a disease, OAB can have significant and broad impacts on the patient’s quality of life (QoL) and activities of daily living, productivity, physical and psychological health, sleep, and sexual function.5 OAB syndrome can also increase risk of incontinence-associated dermatitis and UTI.5
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Read More »A total of 98 women, 18 years or older, with dry OAB (mean duration of OAB symptoms, 1.9 ± 2.67 years), were randomized in this study to receive either dried cranberry powder pill containing 500 mg of proprietary full spectrum dried cranberry fruit (V. macrocarpon, Aiton) or a placebo pill with a mixture of maltodextrin and food grade colors. Data for 60 participants, only those who completed all study visits and complied with the study protocol, was included in the per-protocol population data set. The primary outcome of treatment success, defined as an average of 1 or more void reduction per day, the number and degree of urinary incontinence episodes, urge severity, presence of nocturia and fluid intake, was assessed using a 3-day voiding diary. Secondary measure of treatment success was defined as ≥5-point decrease in the Overactive Bladder Questionnaire Short Form (OABQ-SF) score from baseline compared with 24 weeks. Patient-reported outcomes were also assessed using the Patient Perception of Bladder Condition (PPBC) and Sexual Quality of Life-Female and Pelvic Floor Disability Index 20. The analysis showed that daily intake of dried cranberry powder significantly improved the mean daily micturition numbers by 16.4% (mean difference between cranberry vs placebo, −1.91; p = 0.0406), urgency episodes by 57.3% (7.51 at baseline vs 3.21 at 24-weeks),and patient-reported bladder condition by 39.7% (PPBC scores, 3.70 at baseline vs 2.23 at 24 weeks), compared with baseline at the end of the study period of 24 weeks. Overall, the significant symptom improvements, the authors concluded, make their “findings both novel and clinically meaningful.” They added, “Intake of dried cranberry for a longer duration may lead to significant changes in other variables,” such as mean daily number of nocturia and other patient-reported outcome measures, such as the OABQ-SF severity score. The authors concluded that their data indicate that “daily intake of dried cranberry powder improved daily micturition, urgency episodes and patient reported bladder condition, supporting its use as a safe treatment for OAB.”
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