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Does coffee impact prostate?

One to 3 cups a day can lower your odds of aggressive prostate cancer by nearly a third -- no matter what your health condition is. If you have or used to have prostate cancer, the news could be good for you, too. Researchers also found that 4 or more cups of coffee a day may help delay the disease's progression.

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Some people can’t face the day before their first cup of coffee. It turns out that your mug of joe might offer more benefits than just a morning jolt. Several studies suggest that coffee may lower a man’s odds of getting prostate cancer. The Connection In one study, men who drank 6 or more cups of coffee each day had their chance of prostate cancer cut by almost 20%. Interestingly, it didn’t matter whether they drank caffeinated or decaffeinated coffee. What’s more, the benefit appears to be even bigger for lethal prostate cancer. Men who drank 6 or more cups of coffee had their chances of that cut by almost 60%. But you don’t have to drink java all the time to see an upside. One to 3 cups a day can lower your odds of aggressive prostate cancer by nearly a third -- no matter what your health condition is. If you have or used to have prostate cancer, the news could be good for you, too. Researchers also found that 4 or more cups of coffee a day may help delay the disease's progression. It could also keep prostate cancer from coming back. How Does Coffee Help? We aren’t exactly sure why this popular drink seems to lower chances of certain types of prostate cancer. We do know that coffee has hundreds of active ingredients that can help your health. For example, it's rich in antioxidants like flavonoids and polyphenols. Some of these compounds may prevent damage to your cells and ease inflammation. Scientists did identify two possible contenders for coffee’s cancer-fighting abilities: kahweol acetate and cafestol. These compounds slowed the growth of prostate cancer cells in a recent study. This may explain why men who drink boiled coffee have lower odds of prostate cancer compared to men who drink filtered coffee. Paper filters trap kahweal acetate and cafestol. Since boiled coffee doesn't need a filter, the compounds stay in your cup. Not So Fast The findings are promising, but we need more studies. The current research shows a relationship between coffee consumption and a lower chance of prostate cancer. But they don't prove that drinking coffee can prevent prostate cancer. Clinical trials can test that.

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Is cabbage good for prostate health?

An organic compound found in cruciferous vegetables such as broccoli, cabbage and cauliflower can inhibit the growth of prostate cancer cells by activating a specific gene that encodes phosphatase and tensin homolog (PTEN), a tumour-suppressing enzyme.

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© S. Priyadarshini

An organic compound found in cruciferous vegetables such as broccoli, cabbage and cauliflower can inhibit the growth of prostate cancer cells by activating a specific gene that encodes phosphatase and tensin homolog (PTEN), a tumour-suppressing enzyme. This finding may help design novel therapies for prostate and other types of cancers1. An international research team, including a scientist from the Intonation Research Laboratories in Hyderabad, India, set out to explore the roles of PTEN, a protein encoded by the PTEN gene in cancer. The PTEN enzyme has been found to suppress tumours when it accumulates in the cell membrane. In cell-based experiments, the researchers identified that WWP1, a protein found in cells, disrupts the function of the PTEN enzyme by dissociating it from the membrane. This, in turn, triggered a cascade of molecular events that eventually forms invasive tumours. They found that another gene, known as MYC, also initiates tumour growth by regulating the activity of the WWP1-coding gene. When the WWP1-coding gene was deleted, PTEN was reactivated. This inhibited the growth of cancer cells. The organic compound blocked the activity of Wwp1 and restored the function of the Pten enzyme, shrinking prostate tumours significantly in mice. The treated mice remained fit and fertile, suggesting that the compound could emerge as a safe anti-cancer drug.

References

1. Lee, Y. et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science 364, eaau0159 (2019)

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