Do Olympics ban finasteride?

The World Anti-Doping Agency (WADA) bans the use of Propecia® because its active ingredient, Finasteride, is considered a “masking agent” for some performance-enhancing steroids. Though Finasteride is not a performance-enhancing drug itself, its presence in urine makes it hard to detect banned substances.

hairdr.com - Good For Hair, But Not If You Are In Competitive Athletics

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Good For Hair, But Not If You Are In Competitive Athletics

Posted on April 19, 2008 in Hair Loss

Propecia® is one of the leading medical treatments for hair loss in men, but it becomes a hot topic in sports and Olympics news from time to time. Professional male athletes do their best on and off the field, and that includes looking their best (as we know from Tom Brady’s widely publicized visit with a hair loss specialist a few months ago). However, using Propecia® can sometimes be an issue for competitive athletes. The World Anti-Doping Agency (WADA) bans the use of Propecia® because its active ingredient, Finasteride, is considered a “masking agent” for some performance-enhancing steroids. Though Finasteride is not a performance-enhancing drug itself, its presence in urine makes it hard to detect banned substances. This has posed a problem for a few male athletes, who were unaware of Propecia® being banned in competitive sports by the WADA. A member of the US skeleton team at the 2006 Winter Olympics, Zach Lund, was banned from the competition after Finasteride was detected in a drug test. Goalie Joes Theodore flunked a pre-Olympic screening when he was with the Montreal Canadiens, because of the presence of Finasteride in his urine, and player-coach of the Brazilian soccer team Vasco da Gama, legend Romario de Souza Faria, received a four-month suspension after using Propecia®. All three of these athletes had no intention of providing a faulty urine sample when they took Propecia® as a hair loss treatment. It’s important to note that even though it gets some bad press in instances like these, Propecia® is not dangerous, but is in fact a safe, effective treatment for men experiencing hair loss. In fact, at the time of their trouble with the WADA, all three athletes had healthy heads of hair.

-Doc

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Does 1mg finasteride affect PSA?

Findings Within 48 weeks of randomisation, men aged 40–49 years and 50–60 years who were assigned 1 mg/day finasteride had a median decrease in serum PSA concentration of 40% (95% CI 34–46) and 50% (44–57), respectively.

thelancet.com - Articles Effect of 1 mg/day finasteride on concentrations of serum prostate ...

Background

Use of 5 mg/day finasteride (Proscar) for benign prostatic hyperplasia is known to affect serum concentrations of prostate-specific antigen (PSA). When men taking this treatment undergo screening for prostate cancer, a compensatory adjustment of the PSA concentration (to multiply the value by two) is recommended. Whether this recommendation should apply to men taking 1 mg/day finasteride (Propecia) for the treatment of androgenic alopecia is unknown. We aimed to assess the effect of 1 mg/day finasteride on serum PSA in men aged 40–60 years with male-pattern hair loss.

Methods

Between March 13, 1998, and Jan 12, 2000, 355 men aged 40–60 years with male-pattern hair loss were stratified by age decade (40–49 years and 50–60 years), and randomised in a ratio of four to one to 1 mg/day finasteride or placebo. The primary endpoint was the effect of this treatment for 48 weeks on serum PSA concentration compared with placebo. This trial is in the process of being registered on the US National Institutes of Health website http://www.clinicaltrials.gov/ct/show/NCT00396175 . Analyses were according to protocol.

Findings

Within 48 weeks of randomisation, men aged 40–49 years and 50–60 years who were assigned 1 mg/day finasteride had a median decrease in serum PSA concentration of 40% (95% CI 34–46) and 50% (44–57), respectively. In men assigned placebo, the median changes were 0% [−14 to 14] and a median increase of 13% [2 to 24], respectively.

Interpretation

In men aged 40–60 years, 1 mg/day finasteride for 48 weeks lowers serum PSA concentration. Therefore, the existing recommendation for the adjustment of serum PSA concentration in prostate-cancer screening in men taking 5 mg/day finasteride should also apply to men taking the 1 mg/day preparation for male-pattern hair loss. Research is needed to assess the effect of 1 mg/day finasteride preparation beyond 48 weeks of treatment.

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