Prostate Restored
Prostate Restored
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Results newly reported in JAMA show that the muscle mass of men is not affected by inhibition of 5α-reductase, the enzyme that produces the androgen 5α-dihydrotestosterone (DHT) from testosterone.
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Read More »Results newly reported in JAMA show that the muscle mass of men is not affected by inhibition of 5α-reductase, the enzyme that produces the androgen 5α-dihydrotestosterone (DHT) from testosterone. DHT is a potent testosterone metabolite that has a number of roles in male physiology, including in the embryonic development of the prostate. Inhibitors of 5α-reductase are often prescribed for BPH, as blockade of DHT is known to shrink the hyperplastic prostate tissue. However, the roles of testosterone and DHT in regulating lean body mass have hitherto been difficult to disentangle from the multitude of other complex hormonal interactions that occur. Indeed, the roles of testosterone and DHT in other tissues, such as bone, are also unclear. The 20-week study of 102 healthy men examined the effects of high-dose (2.5 mg per day) dutasteride (a 5α-reductase inhibitor) and testosterone enanthate compared with placebo and testosterone enanthate. All participants were given a long-acting gonadotropin releasing hormone agonist to suppress endogenous testosterone. Each arm was also subdivided into four dosage branches based on the testosterone dose given (50–600 mg per week). In doing so, the subgroups of patients were comparable with respect to their testosterone and DHT levels. The fat-free mass and lean body mass in the two arms increased dose-dependently with respect to testosterone and were not significantly different between the dutasteride and placebo groups. Additionally, inhibiting DHT production did not alter the ability of testosterone to modulate muscle strength, sexual function or prostate volume. Credit: © Auris | Dreamstime.com From a therapeutic perspective, inhibitors of 5α-reductase to treat BPH have long been suspected of causing many adverse effects including reduced muscle mass, reduced bone density and sexual dysfunction. The results of this trial suggest these fears are perhaps overstated. “These findings bode well for the safety of 5α-reductase inhibitors with respect to their effects on muscle, because they indicate that these drugs will not induce muscle loss,” says lead investigator Shalender Bhasin of Boston University School of Medicine. Indeed, the common adverse effects might be related to the age of the patients—approximately 40% of men aged 51–60 years have BPH—rather than the therapeutic regimen.
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Read More »During sexual intercourse, most men ejaculate between 5-10 minutes and research has shown the average time to ejaculate after penetration is 5 1/2 minutes. Usually, ejaculation less than 1 to 1 1/2 minutes after penetration is regarded as premature ejaculation.
During sexual intercourse, most men ejaculate between 5-10 minutes and research has shown the average time to ejaculate after penetration is 5 1/2 minutes. Usually, ejaculation less than 1 to 1 1/2 minutes after penetration is regarded as premature ejaculation. But if this causes no distress to either partner, no treatment is necessarily required. The presence of distress in association with quick ejaculation often indicates the need for treatment. There are a few treatments including behavioural exercises, use of condoms and anaesthetic spray, as well as anti-depressant medication (also known as SSRI). This requires a doctor’s prescription and comes in two forms. SSRI medication is a very successful treatment for depression but it has a significant side effect of delaying ejaculation which is why it's sometimes prescribed for men with premature ejaculation. Want to learn more about premature ejaculation? Check out the information on our Premature Ejaculation page or browse through our resource library for fact sheets, information guides and videos on retrograde ejaculation and other ejaculation and erectile problems.
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Fluxactive Complete is conveniently packed with over 14 essential prostate powerhouse herbs, vitamins and grade A nutrients which work synergistically to help you support a healthy prostate faster
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Ginger has the ability to inhibit the enzyme 5α-reductase, which plays a key role in converting testosterone to DHT (dihydrotestosterone) (9)....
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