Can you grow a new prostate?

The prostate gland has a remarkable ability to regrow itself after hormone-deprivation therapy. A new study from researchers at Memorial Sloan Kettering explains why. The standard treatment for men with advanced prostate cancer is androgen-deprivation therapy.

mskcc.org - New Discovery Explains How the Prostate Gland Regenerates ...

What should I eat when tired?

Foods That Beat Fatigue Unprocessed foods. Fruits and vegetables. Non-caffeinated beverages. Lean proteins. Whole grains and complex carbs. Nuts....

Last updated Oct 15, 2020

What can I expect at my first pelvic floor therapy?

Based on your history and symptoms an exam will be perform. This may include observation and palpation of back, pelvis, hips, abdomen and pelvic...

Last updated Aug 27, 2021

Imagine Your Moment Of Freedom!

Fluxactive Complete is conveniently packed with over 14 essential prostate powerhouse herbs, vitamins and grade A nutrients which work synergistically to help you support a healthy prostate faster

Learn More »

Promotion

Summary The prostate gland has a remarkable ability to regrow itself after hormone-deprivation therapy. A new study from researchers at Memorial Sloan Kettering explains why. The standard treatment for men with advanced prostate cancer is androgen-deprivation therapy. Androgens are hormones that fuel prostate cell growth; removing them with either drugs or surgery causes the prostate gland to shrink by 90%. Nevertheless, the cells that remain can eventually regrow a tumor, and when they do, the tumor is usually resistant to further hormone therapy. It is also more likely to spread to other organs (metastasize). A new study from researchers at Memorial Sloan Kettering provides insight into how the prostate is able to regrow so swiftly. And it is not what the scientists initially expected. “Most people, including me, expected to find a rare population of stem cells that is responsible for regenerating the gland,” says Charles Sawyers, Chair of the Human Oncology and Pathogenesis Program at MSK and the corresponding author on the paper, published May 1 in the journal Science. “But this is not the case.” Instead, he says, nearly all of the cells that persisted after hormone-deprivation therapy contributed to the regeneration of the prostate gland. Most of these were luminal cells, which form the inside of the hollow organ. The findings have implications for how doctors think about prostate cancer treatment. Most people, including me, expected to find a rare population of stem cells that is responsible for regenerating the gland. Charles L. Sawyers physician-scientist

A Cellular Atlas of the Prostate

The investigators made their discovery with the help of a powerful technique called single-cell RNA sequencing (scRNA seq). This method of analysis allows scientists to identify which genes are turned on in many individual cells in a tissue at once. Collaborating with scientists from the Dana Pe’er lab in the Sloan Kettering Institute and Aviv Regev’s lab at the Broad Institute, the team performed scRNA seq on nearly 14,000 cells in the mouse prostate gland. From these data, they were able to completely map out the cell types found in a normal mouse prostate. With the information, they could then determine which cell types remained in the prostate after the mice received androgen-deprivation therapy, and which divided to regrow the gland when androgen was restored. From these analyses, it was clear that nearly all the luminal cells in the prostate were dividing, rather than just a subset — as would be expected if a stem cell population were mainly responsible for regenerating the gland. What’s more, the luminal cells (whose typical function is to secrete fluids) had clearly acquired abilities they don’t usually have in a hormonally intact animal.

What triggers testosterone?

Your hypothalamus releases gonadotropin-releasing hormone (GnRH), which triggers your pituitary gland to release luteinizing hormone (LH). LH then...

Last updated Aug 16, 2018

What food makes you thick?

What Are Some Kinds Of Foods That Help You Get Thicker? Spinach. Spinach is a low-calorie dark leafy green vegetable that is considered a superfood...

Last updated Dec 30, 2018

Promotion

“They became much more stemlike,” says Wouter Karthaus, a senior postdoctoral fellow in the Sawyers lab and the paper’s first author. “Without androgens influencing their gene expression, they were free to turn on other genes and acquire regenerative properties.” In addition to the mouse work, the investigators performed scRNA seq on prostate tissue taken from men who had been treated for prostate cancer. They found a similar pattern of luminal prostate cells that had acquired the attributes of stem cells. This implies that what is true of mice may also be true of men. Human Oncology & Pathogenesis Program Scientists in Memorial Sloan Kettering's Human Oncology and Pathogenesis Program (HOPP) are bridging basic and clinical science to transform cancer care and address major scientific challenges in the era of precision medicine. Learn more

Plastic Identities

The study’s findings contradict a classic model of how stem cells regenerate and repair tissue. By that way of thinking, stem cells are a rare and special type of cell that can give rise to many cell types yet retain a proliferative capacity. But recent studies — including, now, this one — have questioned how broadly this model applies across different organs. At least in the prostate, fully differentiated cells can become stem cells under the right conditions, this study suggests. Prior work from the Sawyers lab showed that some prostate cancer cells possess an ability to change their identity. This is called lineage plasticity. They can, for example, reprogram themselves to become a type of prostate cell that does not require androgen to survive. Lineage plasticity is an important way that prostate cancer cells eventually develop resistance to hormone-blocking therapies. What the latest findings mean for treatment is an open question, but there could be significant implications. “Androgen-deprivation therapy may be a double-edged sword,” Dr. Sawyers says. “Lots of cells die, but the ones that persist acquire this stemlike property.” “It is likely that we push prostate cancer to have a more progenitor-like state during therapy,” Dr. Karthaus adds. The team’s next effort will be to identify the molecular and cellular cues that control this switch in the hope of developing ways to turn it off.

mskcc.org - New Discovery Explains How the Prostate Gland Regenerates ...

Does taking zinc thin your blood?

Side Effects and Warnings According to MayoClinic.com, zinc may increase bleeding risk; hence, people suffering from bleeding disorders or taking...

Last updated Mar 27, 2021

Do doctors recommend curcumin?

In fact, there is not enough reliable evidence in humans to recommend turmeric or curcumin for any condition, according to the National Center for...

Last updated Jan 16, 2022

Promotion

What foods thin your blood?

Blood-thinning foods, drinks, and supplements Turmeric. Ginger. Cayenne peppers. Vitamin E. Garlic. Cassia cinnamon. Ginkgo biloba. Grape seed...

Last updated May 2, 2021

Promotion

Can turmeric reverse osteoarthritis?

Research finds that an ingredient in the spice turmeric can significantly reduce knee pain in people with osteoarthritis – but it won't improve...

Last updated Sep 20, 2021