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Can lack of sleep increase uric acid?

1. Short sleep duration was associated with high uric acid levels, whereas poor sleep quality was associated with low uric acid levels.

2minutemedicine.com - Sleep quality and duration associated with blood uric acid levels
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1. Short sleep duration was associated with high uric acid levels, whereas poor sleep quality was associated with low uric acid levels.

Evidence Rating Level: 2 (Good)

A proper balance of uric acid levels is vital to one’s health, because of its role in antioxidation and neuroprotection. Hyperuricemia affects 20% of people worldwide, and is related to conditions such as gout, chronic kidney disease, and cardiovascular disease, as well as early mortality. However, low uric acid is also related to diseases such as Alzheimer’s and Parkinson’s. Both sleep quality and duration are thought to influence uric acid levels, but previous literature has not studied this association with both sleep factors simultaneously, and the same sample population. The current study from Taiwan examines the correlation between these sleep factors and uric acid levels. The sample included 4,592 adult patients who self-opted for a general health assessment at a university hospital. Sleep duration was assessed as short (< 7 hours), normal (7-9 hours), or long (>9 hours). Sleep quality was assessed using the self-evaluated Pittsburgh Sleep Quality Index (PSQI), which looks at factors such as sleep duration, percent of time spent asleep while in bed, time taken to fall asleep, sleep medication use, and sleep disturbances. The study found that poor quality sleepers were associated with lower uric acid levels (correlation coefficient -0.085, 95% CI -0.161—0.008, P = 0.030). As well, those with short sleep durations were associated with high uric acid levels (correlation coefficient 0.106, 95% CI 0.31-0.181, P = 0.006). Overall, this study elucidates how different sleep factors can be associated with both high and low uric acid levels, as well as provides potential support for guidelines directed at patients with uric acid imbalance.

Click to read the study in PlosONE

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

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Is walnuts high in uric acid?

Good sources of low-purine nuts and seeds include walnuts, almonds, flaxseeds and cashew nuts.

healthxchange.sg - Gout Diet: Foods That Keep Your Uric Acid in Check - HealthXchange.sg

Gout-friendly proteins include eggs, nuts, seeds and cold-water fish. The Dietetics and Food Services from Changi General Hospital explain how these foods can help control gout.

What is gout?

Gout is a form of arthritis that attacks joints and causes acute pain and swelling mostly in the big toe and fingers, and sometimes, in the wrists, elbows, knees and ankles. Gout attacks are triggered by uric acid build-up in the joints. The body produces uric acid whenever it breaks down purine-containing foods.

Gout-friendly diet:

Protein​

Although people with gout should avoid proteins with very high purine concentrations such as organs, seafood and shellfish, and meats like venison, sausages and bacon, they can still eat proteins with lower purine content moderately.

Eggs

Cold-water fish

Essential fatty acids found in cold-water fish such as tuna can reduce gout inflammation. However, to prevent a gout flare-up, limit the intake of fish to one serving per day as it still contains purines.

Nuts and seeds

A gout-friendly diet should include two tablespoons of nuts and seeds every day. Good sources of low-purine nuts and seeds include walnuts, almonds, flaxseeds and cashew nuts.

Click on the next page for more information on gout-friendly foods.

Ref: S13

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