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High creatinine levels may indicate one of several underlying health conditions requiring medical treatment. Following treatment of the underlying cause, creatinine levels should return to normal.
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Read More »High creatinine levels may indicate one of several underlying health conditions requiring medical treatment. Following treatment of the underlying cause, creatinine levels should return to normal. Creatinine is a waste product of the muscles. In a healthy body, the kidneys filter creatinine from the blood and excrete it through the urine. High levels of creatinine can indicate kidney issues. In this article, we explore what creatinine is and what can cause high levels. We also look at symptoms of high creatinine, when to worry about creatinine levels, and the treatment options. What is creatinine? Share on Pinterest nensuria/Getty Images Creatinine is a byproduct of normal muscle function. It is a metabolite of creatine phosphate, which the muscles use as an energy source. The greater someone’s muscle mass, the higher their creatinine levels. For this reason, males tend to have higher creatinine levels than females. The primary way in which the body removes creatinine from the blood is by filtration through the kidneys and then excretion in the urine. What are normal and high levels? The creatinine levels that experts consider to be normal may vary among different hospitals and laboratories. According to the British Medical Journal, the usual reference range for serum creatinine is 60–110 micromoles per liter (mcmol/l), or 0.7–1.2 milligrams per deciliter (mg/dl), for males and 45–90 mcmol/l (0.5–1.0 mg/dl) for females. If creatinine is above these levels, doctors may consider it high. However, their decision will depend on someone’s muscle mass and certain other factors, such as age, sex, and hydration levels. How do doctors test for creatinine levels? Doctors take a blood sample to test creatinine levels. They then use a formula to estimate creatinine clearance. In some cases, they may also request that the individual collects all of their urine over 24 hours and brings it to the laboratory. The doctor can then compare the urinary creatinine level with that of the blood. These results show how much creatinine the kidneys are filtering out of the body and how well they are functioning. Causes of high creatinine levels High creatinine levels usually indicate that the kidneys are not working as they should. Possible causes of this dysfunction include: a kidney infection
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