Can cranberry juice lower PSA?

prostatecancerinfolink.net - So drinking cranberry juice can lower your PSA level, but what does that ...

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As we have noted numerous times before, there are all sorts of things that can be done to lower one’s PSA level, but knowing whether these effects are clinically meaningful is a very different issue.

In a new paper just published by Student et al. (from a research team in the Czech Republic), the authors have shown that prostate cancer patients who were scheduled to undergo radical prostatectomy as a treatment for prostate cancer could lower their PSA levels by drinking cranberry juice (made by dissolving 1,500 mg of cranberry fruit powder) for 30 days prior to their surgery. But what does this actually mean?

Student et al. randomized 64 patients to drinking the cranberry juice or to drinking a placebo for an average of 30 days prior to their radical prostatectomy. Here is a summary of what they found: Compared to the men taking the placebo, the men drinking the cranberry juice Experienced a drop of 22.5 percent in their PSA levels prior to their surgery. Exhibited “a trend to down-regulation” of urinary beta-microseminoprotein (MSMB) and serum gamma-glutamyltranspeptidase Exhibited a trend to upregulation of IGF-1 Showed no changes in prostate tissue markers or in composition and concentration of phenolics in urine

The authors conclude that

Daily consumption of a powdered cranberry fruit lowered serum PSA in patients with prostate cancer. The whole fruit contains constituents that may regulate the expression of androgen-responsive genes. However, there is no sign from these data that drinking cranberry juice actually made any clinical difference to the outcomes for these patients. Of course drinking cranberry juice is unlikely to do you any significant harm, so if you like drinking it, go right ahead. In a previous paper the same group of authors say they have also shown that drinking cranberry juice can lower PSA levels in men who were biopsy negative for prostate cancer and for chronic non-bacterial prostatitis. Of course if you have been drinking cranberry juice on a regular basis (whether you have prostate cancer or not), then what is clear is that you and your doctors had better be aware that this can lower PSA levels. In other words, a man with a PSA level of 2.5 ng/ml who has been regularly drinking cranberry juice might have a “real” PSA level of more like 4.0 ng/ml, which might make it wise for him to realize that he is at risk for prostate cancer. Now what might be interesting would be to see whether drinking cranberry juice might help men with low-risk prostate cancer to stay on active surveillance as opposed to having treatment they they don’t really need (because the cranberry juice might help to keep their PSA levels a little lower).

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Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: cranberry, juice, PSA, risk |

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What medications can decrease PSA levels?

theoncologypharmacist.com - Statins, Other Common Drugs Lower PSA Levels

Use of nonsteroidal anti-inflammatory drugs (NSAIDS), statins, or thiazide diuretics significantly lowers prostate-specific antigen (PSA) levels in men without a history of prostate cancer, new data indicate. Steven L. Chang, MD, and his associates at Stanford University School of Medicine evaluated the impact of 10 commonly used medications, used singly or in combination, on PSA test readings in men ≥40 years old without prostate cancer. A total of 1864 men who participated in the National Health and Nutrition Examination Survey were included in the study, published online August 2 in the Journal of Clinical Oncology. The researchers found that use of NSAIDS, statins, or thiazide diuretics was inversely associated with PSA levels. After 1 year, PSA levels were 1%, 3%, and 6% lower, respectively, in men who used these agents s than in men who did not. The differences were more pronounced with prolonged use. At 5 years, PSA levels were lower by 6%, 13%, and 26%, respectively, for users of NSAIDS, statins, or thiazide diuretics than for nonusers. The reduction in PSA levels was greatest in men who used statins and thiazide diuretics—36% after 5 years. Concurrent use of calcium channel blockers minimized or negated the PSA-lowering effect. The authors note that PSA screening is widely practiced in men >50 years of age, a population with a particularly high rate of medication use. If the lower PSA levels found in men taking commonly used medications results in a delayed diagnosis of prostate cancer, a “medication-adjusted” PSA threshold for prostate cancer screening may be needed, they say.