Prostate Restored
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Yes, it is possible for someone with a Y chromosome to become pregnant and give birth to a child. But it's extremely rare. One of the most important requirements for pregnancy is having a uterus. Most people with a Y chromosome don't have a uterus and without one, there is no place for a baby to grow.
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Read More »Yes, it is possible for someone with a Y chromosome to become pregnant and give birth to a child. But it's extremely rare. One of the most important requirements for pregnancy is having a uterus. Most people with a Y chromosome don't have a uterus and without one, there is no place for a baby to grow. No uterus, no pregnancy. So how is it possible for people to have both a Y chromosome and a uterus? One possibility is that their Y chromosome lacks what it takes to make a male. Unfortunately, scientists don't know the rest of the story. What we do know is that every once in a while, an XY person develops into a female. These individuals could be female in every way, but they almost always lack working ovaries and a uterus. Which means that they can't get pregnant. For reasons we don't understand, on very rare occasions, an XY female does have a uterus. But she still needs a donated egg, since she can't make one herself (no ovaries). There are a handful of cases where individuals with a Y chromosome, a uterus, and a donated egg have become pregnant and given birth to a child. One such mom even had twins! What I thought I'd do for the rest of the article is talk about why having a Y chromosome almost always keeps someone from having a uterus. Then I'll also go over some natural conditions people have where they look female but have a Y chromosome. Anyone with a uterus has the potential to have a baby, even if they carry a Y chromosome. Created using BioRender
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Read More »SRY is important in getting the ball rolling on making testes. And testes are important for making lots of testosterone and other androgens. The testosterone then goes on to finish the job of making male parts. But testosterone doesn't do this on its own. It needs to work with a certain protein called the androgen receptor (AR). Testosterone and AR pair up to turn lots of different genes on and off. The pattern of genes that are ultimately on makes a fertile male. Both a functioning SRY gene and androgen receptor are required to tell the body to make male parts. Created using BioRender Since most females don't have a Y chromosome, there is no SRY gene to trigger male development. Instead of making testes, females develop ovaries. And they make lots of estrogen instead of testosterone. The estrogen pairs up with the estrogen receptor (ER) to turn a different set of genes on and off. This pattern of genes leads to a uterus, ovaries, and the other parts of a fertile female. So to end up a fertile male, you need working SRY and AR genes. To end up a fertile female, you need for the SRY gene to be absent and for the ER gene to work right*. (*This is of course a gross oversimplification. Lots of other genes are needed to make a fertile male and female.)
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Read More »XY females may have a broken SRY gene or lack androgen receptor, so they do not have male parts. Created using BioRender One of the few differences between XX females and XY females is that nearly all XY females don't have ovaries and a uterus. Instead, XY females typically have undeveloped testes inside their bodies. As I mentioned before, in very rare cases, an XY female does have a uterus. Scientists still don't know how this happens. But for these rare individuals, having a Y chromosome and becoming pregnant is possible.
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