Photo: Brett Sayles

Can a man's prostate grow back?

The prostate can regenerate when androgen is restored. A team of researchers led by Dr. Charles Sawyers of Memorial Sloan Kettering Cancer Center and Aviv Regev at the Broad Institute studied how normal prostate tissue restores itself after androgen deprivation therapy.

nih.gov - New insight into regenerating prostate tissue | National Institutes of Health ...

Does ashwagandha help clear skin?

Ashwagandha root has both antibacterial and antimicrobial properties which protect the skin from infections or acne. It also boosts the collagen in...

Last updated May 31, 2022

Would blood work show signs of lymphoma?

Blood Tests A low level of red blood cells, white blood cells or platelets may indicate that the lymphoma is present in the bone marrow and/or blood.

Last updated Dec 15, 2021

Promotion

New insight into regenerating prostate tissue

At a Glance Researchers studying how the prostate regenerates after hormone therapy found that an unexpected population of cells plays an important role. Understanding the process underlying prostate regeneration could lead to improved therapies for prostate cancer.

Memorial Sloan Kettering Cancer Center

In prostate cancer, abnormal cells grow in the tissues of the prostate, a gland in the male reproductive system. About 1 out of 5 men in the U.S. will be diagnosed with prostate cancer. It is most common in older men. Hormone therapy is standard treatment for men with advanced prostate cancer. Male sex hormones called androgens, which include testosterone, can cause prostate cancer to grow. During treatment, doctors use drugs, surgery, or other hormones to reduce androgens or block them from working. Androgen deprivation shrinks the prostate gland substantially. This is due to the loss of luminal cells, which form the inside of the hollow prostate. The prostate can regenerate when androgen is restored. A team of researchers led by Dr. Charles Sawyers of Memorial Sloan Kettering Cancer Center and Aviv Regev at the Broad Institute studied how normal prostate tissue restores itself after androgen deprivation therapy. The work was funded in part by NIH’s National Cancer Institute (NCI). The findings appeared in Science on May 1, 2020. To explore cell populations in the prostate, the team profiled more than 13,000 cells collected from mouse prostate glands. Using a technique called single-cell RNA sequencing, which can be used to distinguish different cell populations, they identified 22 distinct subsets of cells. Among these were three subsets of luminal cells. The researchers then studied gene expression of these luminal cells during castration and prostate regeneration. They found that in castrated mice, rare populations of luminal cells became “stemlike,” expressing genes similar to stem cells. Stem cells can develop into many different types of cells, and are known to play a critical role in regenerating some types of tissues. The researchers also identified a large population of differentiated luminal cells that aid in prostate regeneration. Differentiated cells are mature cells that usually lack stem cells’ ability to self-renew. Further testing in mice and organoids (artificial masses of cells grown to resemble organs) gave insight into how both these types of luminal cells aid in regeneration. Finally, the researchers analyzed human prostate tissue. They identified similar luminal populations in samples from prostate cancer patients treated with androgen deprivation therapy. “Androgen-deprivation therapy may be a double-edged sword,” Sawyers says. “Lots of cells die, but the ones that persist acquire this stemlike property.” The findings suggest that prostate regeneration after hormone therapy may be driven by differentiated and stemlike luminal cells rather than just by a rare population of stem cells. Understanding how luminal cells acquire this enhanced potential to regenerate could have implications for improved prostate cancer therapy.

—by Erin Bryant

Is garlic high in testosterone?

Studies have shown that garlic can naturally boost testosterone levels. Diallyl disulfide is the chemical in garlic that helps in the production of...

Last updated Feb 28, 2022

What is the 3 day rule for guys?

Popularized by the romcom, the three-day dating rule insists that a person wait three full days before contacting a potential suitor. A first-day...

Last updated May 3, 2019

Promotion

How do you feel if your prostate is swollen?

You can't urinate at all. You have to pee frequently, it's painful, and you have fever and chills. You have blood in your urine. You feel a great deal of pain in your lower belly and urinary tract.

webmd.com - BPH Symptoms: What Are The Signs Of An Enlarged Prostate? - WebMD

As they age, some men may notice that they have trouble peeing. You might find it hard to start going, or perhaps the stream starts and stops several times. These are just two possible signs of benign prostatic hyperplasia, called BPH, which is an enlarged prostate. This gland, which grows during early puberty and then again around age 25, becomes enlarged in many men. It can pinch your urethra, the tube that carries urine from your bladder through your penis. Your bladder walls may also grow thicker. This is the most common prostate problem in men 50 and older. It’s good to know the symptoms of BPH because you might want to talk with your doctor.

What medications can cause prostate problems?

Prescription medications to avoid Diuretics. Diuretics, or water pills, are medications that remove extra fluid from the body. ... Antidepressants....

Last updated Feb 27, 2022

How do you stop prostatitis flare ups?

Consuming drinks free of caffeine to urinate more often and flush the bacteria out of the bladder. Take a break from acidic and spicy foods,...

Last updated Jun 14, 2018

Imagine Your Moment Of Freedom!

Fluxactive Complete is conveniently packed with over 14 essential prostate powerhouse herbs, vitamins and grade A nutrients which work synergistically to help you support a healthy prostate faster

Learn More »

Promotion

How do you overcome bladder anxiety?

Meditation and breathing exercises to help you control anxiety and relax your urinary tract. Psychotherapy, or talk therapy, to treat mental health...

Last updated Feb 2, 2021

Promotion

What happens if you drink straight olive oil?

“Drinking small amounts of olive oil should not cause harm or elicit negative side effects for most people,” says Laing. Some might experience...

Last updated Jan 25, 2020